Group I | Group II | Group III | p Value | |
Screening round I | ||||
Eligible invitees, n | 2385 | 2428 | 2416 | |
Participation rate, n (%) | 1543 (64.7) | 1481 (61.0) | 1499 (62.0) | |
Positivity rate, n (%) | 139 (9.0) | 127 (8.6) | 114 (7.6) | |
Detection rate of | ||||
Advanced neoplasia, n (%) | 55 (3.6) | 43 (2.9) | 50 (3.4) | |
Advanced adenoma, n (%) | 51 (3.3) | 33 (2.2) | 42 (2.8) | |
Colorectal cancer n (%) | 4 (0.3) | 10 (0.7) | 8 (0.5) | |
Screening round II | ||||
Eligible invitees, n | 2034 | 2048 | 2029 | |
Participation rate, n (%) | 1286 (63.2) | 1280 (62.5) | 1298 (64.0) | 0.04 |
Participant round I, n (%) | 1166 (89.8) | 1123 (90.9) | 1138 (91.3) | |
Non-participant round I, n (%) | 120 (16.3) | 157 (19.3) | 160 (20.5) | |
Positivity rate, n (%) | 70 (5.4) | 85 (6.6) | 75 (5.8) | 0.40 |
Participant round I, n (%) | 60 (5.1) | 76 (6.8) | 64 (5.6) | |
Non-participant round I, n (%) | 10 (8.3) | 9 (5.7) | 11 (6.9) | |
Detection rate of | ||||
Advanced neoplasia, n (%) | 25 (1.9) | 27 (2.1) | 22 (1.7) | 0.77 |
Advanced adenoma, n (%) | 24 (1.9) | 23 (1.8) | 20 (1.5) | |
Colorectal cancer, n (%) | 1 (0.1) | 4 (0.3) | 2 (0.2) | |
Detection rate of | ||||
Advanced neoplasia, n (%) | 25 (1.9) | 27 (2.1) | 22 (1.7) | 0.77 |
Participant round I, n (%) | 19 (1.6) | 23 (2.1) | 18 (1.6) | |
Non-participant round I, n (%) | 6 (5.0) | 4 (2.5) | 4 (2.5) |
Groups I, II and III: Individuals were invited for two 1-sample FIT screening rounds after an interval of 1, 2 or 3 years, respectively.
Screened individuals with a positive test result in the first screening round, subjects who fulfilled the exclusion criteria of the first round, individuals who had moved out of the region, had died, or reached >75 years were not invited for a second FIT-based screening round.
Advanced neoplasia was defined as a colorectal cancer and an adenoma ≥10 mm, an adenoma with ≥25% villous histology or with high grade dysplasia.
FIT, faecal immunochemical test (OC-Sensor Micro), cut-off value 50 ng haemoglobin/ml.