Cumulative risk (%) of non-colonic and non-endometrial cancers according to type of mismatch repair gene mutation by age 70 years
| Tumour site | Mutation carriers | MLH1 | MSH2 | MSH6 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | M | F | All | M | F | All | M | F | All | M | F | |
| Gastric8 9 11–13 17 19 | 0.7/9.4/0.7 | 6.2/6.7 | 2.0/2.6 | 2.1/3/5/6/6.1/10.9 | 0.2/4.3/5.2/6/7/7.8 | 0/0/0/10.4 | ||||||
| Small bowel9 11–13 15 19 | 0.6/2.5/4.2 | 4.1/6.1/12 | 2.7/3.9/4.1 | 0.4/4.4/4.5/7.2/8 | 1.1/1.3/4.5/5.9/8 | 0/0/0/3 | ||||||
| Biliary tract8 11 13 | 0.6/1.4/2 | 1.9/3 | 0.02/0.4 | 0/0 | ||||||||
| Pancreas11 20 | 0.4/3.7 | 0 | 0.7 | 0 | ||||||||
| Urinary tract8 9 11–13 18 | 1.9/3.2/4/8.4 | 0.2/1.3/2.8 | 3.7/15.6 | 1.1/2.4 | 2.2/4.1/12 | 27.8/18.2 | 11.9/8.4 | 0/0.7 | 2.6 | 0 | ||
| Upper urinary tract12 18 19 | 6.0 | 9.1/9.4 | 5.4/6.0 | 1 | 2.1/4.8 | 2.4/0.4 | 15 | 5.9/20.3 | 5.8/9.1 | 1.5 | 1.3 | 0 |
| Bladder18 19 | 5.5/16.4 | 1.9/3.5 | 1 | 10.8 | 0 | 8 | 12.3 | 2.6 | 1 | 1.3 | 0 | |
| Ovaries8–13 19 | 6.1/8/12/13.5 | 3.4/3.9/5/5.5/6.3/20 | 7.5/8.3/10/10.4/11.6/24 | 0/1.0/10 | ||||||||
| Brain8 9 11 12 | 3.4/3.7 | 0/0.3/1.7 | 1.2/2.5/6.3 | 0 | ||||||||
| Prostate11 12 19 | 9.1/30 | 0 | 6/18 | 0/4 | ||||||||
| Breast12 16 19 | 5.4/14.4 | 18/17 | 1.5/12 | 13 | ||||||||