Table 2

Performance of KRAS, BRAF and PIK3CA mutation signatures in training and validation set

KRAS signature BRAF signature PI3K signature
Training set (n=381)
 Sensitivity (%)919075
 Specificity (%)629280
 Accuracy (%)729179
 Area under the ROC curve* 0.8460.9480.853
 95% CI(0.801 to 0.883)(0.912 to 0.972)(0.803 to 0.894)
 z statistic16.33823.25411.868
 Significance level P (area=0.5)<0.0001<0.0001<0.0001
Validation set (n=80)
 Sensitivity (%)9310069
 Specificity (%)659378
 Accuracy (%)779375
 Area under the ROC curve (AUC)0.8720.9810.812
 95% CI(0.770 to 0.941)(0.886 to 1.000)(0.686 to 0.904)
 z statistic8.57924.3504.818
 Significance level P (area=0.5)<0.0001<0.0001<0.0001
  • * Calculated from training samples used for each signature (AUC).