Vancomycin treatment of diet-induced obese mice results in a major disturbance in the gut microbiota
| Lean | DIO | DIO + vancomycin | |
| Phylum‡ | |||
| Firmicutes | 60.7±2.8 | 70.2±2.4* | 53.9±0.4††† |
| Bacteroidetes | 30.0±2.3 | 19.5±1.4* | 3.5±1.9††† |
| Deferribacteria | 7.1±2.2 | 4.7±1.6 | 0.7±0.3† |
| Proteobacteria | 2.7±0.4 | 3.5±1.0 | 37.7±2.5††† |
| Actinobacteria | 2.5±0.7 | 2.1±0.5 | 4.1±1.6 |
| Family | |||
| Clostridiaceae | 30.6±4.1 | 25.4±3.0 | 3.9±1.5††† |
| Bacteroidaceae | 16.0±1.2 | 11.6±1.0* | 1.5±0.6††† |
| Lactobacillaceae | 4.9±0.9 | 13.6±2.7** | 19.3±4.3 |
| Bifidobacteriaceae | 2.4±0.7 | 1.2±0.5 | 4.1±1.6 |
| Porphyromonadaceae | 2.3±0.5 | 1.4±0.2 | 0.1±0.1††† |
| Alcaligenaceae | 1.0±0.4 | 0.0±0.0* | 6.9±0.9††† |
| Streptococcaceae | 0.4±0.1 | 0.6±0.1* | 2.0±0.5†† |
| Desulfovibrionaceae | 0.8±0.3 | 0.6±0.1 | 1.7±0.4†† |
| Enterobacteriaceae | 0.0±0.0 | 0.0±0.0 | 28.0±0.9††† |
| Genus | |||
| Clostridium | 30.1±4.1 | 25.1±3.1 | 3.8±1.3††† |
| Bacteroides | 7.4±0.7 | 3.3±0.5*** | 0.3±0.1††† |
| Lactobacillus | 4.9±0.9 | 13.5±2.7** | 19.6±4.2 |
| Odoribacter | 2.5±0.5 | 1.1±0.2* | 0.0±0.0††† |
| Bifidobacterium | 2.4±0.7 | 1.2±0.5 | 4.1±1.6 |
| Lactococcus | 0.4±0.1 | 0.6±0.1* | 1.6±0.2††† |
| Desulfovibrio | 0.8±0.3 | 0.6±0.1 | 1.7±0.4†† |
| Sutterella | 1.0±0.4 | 0.0±0.0* | 6.9±0.9††† |
Statistical significance was determined using a two-tailed unpaired t test; p value ≤0.05*; ≤0.01**; ≤0.001*** between lean and diet-induced obese (DIO) mice and p<0.05†; p<0.01††; p<0.001††† between diet-induced obesity and vancomycin-treated diet-induced obese mice.
↵‡ Values are mean percentage read number ±SEM, n=9–10.