Surveillance protocol in LS
| Site of cancer | Lower age limit (years) | Examination | Interval (years) |
|---|---|---|---|
| Colorectum | 20–25 | Colonoscopy | 1–2 |
| Uterus/ovaries | 35–40 | Offer gynaecological examination, transvaginal ultrasound, aspiration biopsy, discuss pros and cons | 1–2 |
| Stomach | 30–35 | Upper gastrointestinal endoscopy only recommended in LS families from countries with high incidence of gastric cancer, preferably in research setting; Screening of all carriers >25 years for H pylori infection | 1–2 |
| Urinary tract | 30–35 | Surveillance (by urine cytology and ultrasound) of MSH2 carriers only in research setting or if results are systematically collected by LS registry | 1 |
LS, Lynch syndrome.