Table 1

Clinical features and mutant GNAS status of pancreatic juice of 78 sporadic and pancreatic screening-identified cases of IPMN

Case	Diagnostic test	Risk group	Gender	Age	Cyst number^*	Tumour location^†	Tumour size^† (mm)	Mural nodule (EUS)	Pathological grade	GNAS status in juice		GNAS status in resected IPMN
Case	Diagnostic test	Risk group	Gender	Age	Cyst number^*	Tumour location^†	Tumour size^† (mm)	Mural nodule (EUS)	Pathological grade	Mutation score^‡	Mutation	GNAS status in resected IPMN
1	Pathology	Sporadic	Male	74	2	Head	50	21 mm	High	6	R201H
2	Pathology	Sporadic	Male	49	2	Head	15	5 mm	High	5	R201C	R201C
3	Pathology	Sporadic	Female	72	2	Body	16	Not detected	Intermediate	5	R201C, R201H	R201H
4	Pathology	Sporadic	Female	66	3	Head	10	Not detected	Intermediate	5	R201C	R201C
5	Pathology	Sporadic	Male	64	10	Head	30	Not detected	Intermediate	5	R201C
6	Pathology	Sporadic	Female	66	8	Head	60	Not detected	Intermediate	8	R201H
7	Pathology	Sporadic	Female	66	1	Head	6	Not detected	Intermediate	2	R201C, R201H
8	Pathology	Sporadic	Female	59	15	Tail	15	6 mm	Intermediate	2	R201C	R201C
9	Pathology	Familial	Female	72	1	Tail	6	Present	Intermediate	4	R201C	R201C
10	Pathology	Sporadic	Female	62	3	Body	15	Not detected	Intermediate	0	WT	WT
11	Pathology	PJS	Female	46	1	Uncinate	10	Not detected	Intermediate	0	WT	WT
12	Pathology	Sporadic	Male	48	1	Head	5	Not detected	Low	1	R201C
13	Pathology	Familial	Male	56	1	Head	15	Not detected	Low	0	WT	WT
14	Pathology	BRCA2^§	Female	60	1	Tail	6	Not detected	Low	0	WT
15	Imaging	Sporadic	Male	76	12	Body	18	Not detected		6	R201C
16	Imaging	Sporadic	Male	74	1	Head	15	Not detected		5	R201C
17	Imaging	Sporadic	Female	86	1	Uncinate	12	Not detected		4	R201C
18	Imaging	Sporadic	Female	64	3	Body	12	Not detected		3	R201C
19	Imaging	Sporadic	Male	57	3	Body	16	Present 5 mm		2	R201C
20	Imaging	Sporadic	Female	71	2	Uncinate	6	Not detected		2	R201C
21	Imaging	Sporadic	Male	60	2	Head	16	Not detected		5	R201C, R201H
22	Imaging	Sporadic	Female	53	2	Body	6.4	Not detected		4	R201C, R201H
23	Imaging	Sporadic	Male	75	3	Head	23	Not detected		7	R201H
24	Imaging	Sporadic	Female	63	3	Body	19	Not detected		4	R201H
25	Imaging	Familial	Male	67	3	Tail	9	Not detected		8	R201C
26	Imaging	Familial	Female	59	5	Tail	12.7	Not detected		7	R201C
27	Imaging	Familial	Female	46	1	Head	9	Not detected		7	R201C
28	Imaging	Familial	Female	64	4	Head	5.2	Not detected		5	R201C
29	Imaging	Familial	Female	44	2	Tail	11	Not detected		4	R201C
30	Imaging	Familial	Male	58	1	Body	5	Not detected		4	R201C
31	Imaging	Familial	Male	66	6	Body	8.5	Not detected		3	R201C
32	Imaging	Familial	Female	60	2	Head	8	Not detected		3	R201C
33	Imaging	Familial	Female	58	15	Tail	8	Not detected		2	R201C
34	Imaging	Familial	Female	52	1	Body	5.4	Not detected		2	R201C
35	Imaging	Familial	Male	62	4	Tail	7	Not detected		2	R201C
36	Imaging	Familial	Female	62	9	Tail	6	Not detected		1	R201C
37	Imaging	Familial	Female	46	4	Body	8	Not detected		1	R201C
38	Imaging	Familial	Female	59	2	Tail	9	Not detected		1	R201C
39	Imaging	Familial	Male	61	5	Tail	7	Not detected		1	R201C
40	Imaging	Familial	Male	67	2	Body	5	Not detected		6	R201G
41	Imaging	Familial	Male	63	15	Body	16	Present		13	R201H
42	Imaging	Familial	Male	56	2	Body	14	Not detected		11	R201H
43	Imaging	Familial	Female	79	4	Tail	15	Not detected		9	R201H
44	Imaging	Familial	Male	53	2	Body	12	Not detected		8	R201H
45	Imaging	Familial	Male	63	6	Tail	18	Not detected		6	R201H
46	Imaging	Familial	Male	70	8	Head	5	Not detected		6	R201H
47	Imaging	Familial	Male	71	2	Body	8	Not detected		5	R201H
48	Imaging	Familial	Male	70	7	Tail	5	Not detected		4	R201H
49	Imaging	Familial	Female	57	6	Body	8	Not detected		4	R201H
50	Imaging	Familial	Male	54	2	Body	7	Not detected		4	R201H
51	Imaging	Familial	Male	61	2	Body	5	Not detected		2	R201H
52	Imaging	Familial	Female	56	4	Body	5	Not detected		1	R201H
53	Imaging	Familial	Female	46	3	Body	6.3	Not detected		2	R201S
54	Imaging	Sporadic	Male	59	1	Head	13	Not detected		0	WT
55	Imaging	Sporadic	Female	75	2	Body	19	Present 3 mm		0	WT
56	Imaging	Sporadic	Female	49	1	Tail	21	Not detected		0	WT
57	Imaging	Sporadic	Male	76	1	Head	28	Not detected		0	WT
58	Imaging	Sporadic	Male	65	4	Head	16	Not detected		0	WT
59	Imaging	Familial	Female	55	1	Uncinate	12	Not detected		0	WT
60	Imaging	Familial	Male	58	8	Head	11	Not detected		0	WT
61	Imaging	Familial	Male	50	10	Tail	11	Not detected		0	WT
62	Imaging	Familial	Female	75	6	Tail	21	Present		0	WT
63	Imaging	Familial	Male	63	8	Tail	18	Not detected		0	WT
64	Imaging	Familial	Male	63	2	Head	28	Not detected		0	WT
65	Imaging	Familial	Male	58	1	Head	5	Not detected		0	WT
66	Imaging	Familial	Female	61	4	Tail	6	Not detected		0	WT
67	Imaging	Familial	Female	51	4	Tail	6	Not detected		0	WT
68	Imaging	Familial	Male	74	2	Uncinate	6	Not detected		0	WT
69	Imaging	Familial	Female	75	4	Tail	6	Not detected		0	WT
70	Imaging	Familial	Female	50	1	Tail	6.7	Not detected		0	WT
71	Imaging	Familial	Female	53	4	Body	5	Not detected		0	WT
72	Imaging	Familial	Male	44	1	Head	8	Not detected		0	WT
73	Imaging	Familial	Male	57	3	Body	5	Not detected		0	WT
74	Imaging	Familial	Female	53	4	Body	6.4	Not detected		0	WT
75	Imaging	Familial	Female	55	2	Tail	6	Not detected		0	WT
76	Imaging	Familial	Male	61	1	Body	5.8	Not detected		0	WT
77	Imaging	BRCA1^§	Female	55	3	Body	8	Not detected		0	WT
78	Imaging	BRCA2^§	Male	52	8	Body	5	Not detected		0	WT

↵* Cysts seen by EUS.
↵† Tumour location and size of the largest cyst.
↵‡ Mutation score =total number of positive wells with confirmed GNAS mutations by pyrosequencing.
↵§ Germline mutation carrier.
EUS, endoscopic ultrasonography; HRM, high-resolution melt-curve analysis; IPMN, intraductal papillary mucinous neoplasm; PJS, Peutz–Jeghers syndrome; WT, wild-type.