Table 3

Associations between pancreatic juice GNAS and clinical variables in 111 subjects with pancreatic cysts

	GNAS mutation (n)	GNAS WT (n)	Univariate		Multivariate
	GNAS mutation (n)	GNAS WT (n)	p Value	HR (95% CI)	p Value
Mean (SD) age (years)	58.4 (9.6)	62.0 (9.2)	0.0492
Gender
Male	32	25	0.5952
Female	33	21	0.5952
Background
Sporadic	19	5	0.0206	2.616 (0.837 to 8.171)	0.0980
High-risk individuals	46	41	0.0206	2.616 (0.837 to 8.171)	0.0980
High-risk subgroup^*
Familial	45	32	0.0053	Not applicable
Familial + germline mutation^†	1	9	0.0053	Not applicable
Cyst number
Solitary	15	22	0.0064	2.584 (1.063 to 6.289)	0.0362
Multiple	50	24	0.0064	2.584 (1.063 to 6.289)	0.0362
Tumour size
≤3 mm	5	12	0.0080	2.585 (0.770 to 8.685)	0.1244
>3 mm	60	34	0.0080	2.585 (0.770 to 8.685)	0.1244
Cyst location
Head and uncinate	22	16	0.9184
Body and tail	43	30	0.9184
Multiseptal formation
Absent	28	30	0.0214	1.375 (0.567 to 3.336)	0.4807
Present	37	16	0.0214	1.375 (0.567 to 3.336)	0.4807
Duct communication
Absent	49	32	0.4964
Present	16	14	0.4964
Mural nodule
Absent	57	44	0.1907
Present	8	2	0.1907
Dilation of the branch ducts
Absent	54	34	0.2406
Present	11	12	0.2406
Dilation of the main pancreatic duct
Absent	51	38	0.5892
Present	14	8	0.5892
Chronic pancreatitis
Absent	48	34	0.9937
Present	17	12	0.9937