Results of logistic regression to assess the effect of genotype at each of the 10 risk loci for samples with genotypes at all 10 single nucleotide polymorphisms and the effect of genotype, age, gender and family history (FH) for study populations where study design did not involve case or control selection on the basis of FH criteria (see table 2)
| SNP | Location | Estimate | SE | Pr(>|z|) | OR | Lower 95% CI | Upper 95% CI |
| Study populations with SNP genotype data for all 10 risk loci (n=39 266) | |||||||
| rs10411210 | 19q13 | 0.12 | 0.02 | 2.07×10−6 | 1.13 | 1.07 | 1.18 |
| rs9929218 | 16q22 | 0.11 | 0.02 | 1.60×10−11 | 1.11 | 1.08 | 1.15 |
| rs6983267 | 8q24 | 0.17 | 0.01 | <2×10−16 | 1.19 | 1.15 | 1.22 |
| rs4779584 | 15q23 | 0.13 | 0.02 | 6.86×10−14 | 1.14 | 1.10 | 1.18 |
| rs4939827 | 18q21 | 0.19 | 0.01 | <2×10−16 | 1.21 | 1.18 | 1.25 |
| rs3802842 | 11q23 | 0.13 | 0.02 | <2×10−16 | 1.14 | 1.11 | 1.18 |
| rs10795668 | 10p14 | 0.11 | 0.02 | 6.53×10−13 | 1.12 | 1.09 | 1.15 |
| rs16892766 | 8q23 | 0.20 | 0.03 | 3.32×10−15 | 1.23 | 1.16 | 1.29 |
| rs961253 | 20p12 | 0.10 | 0.02 | 4.68×10−12 | 1.11 | 1.08 | 1.14 |
| rs4444235 | 14q22 | 0.09 | 0.01 | 2.77×10−9 | 1.09 | 1.06 | 1.12 |
| Study populations with genotypes for all 10 risk loci; not selected for FH (n=11 324) | |||||||
| Age | −0.01 | 0.00 | 4.16×10−5 | 0.99 | 1.00 | 0.99 | |
| Gender M>F | 0.00 | 0.04 | 0.97 | 1.00 | 1.08 | 0.93 | |
| FH | 0.51 | 0.06 | <2×10−16 | 1.66 | 1.87 | 1.48 | |
| rs10411210 | 19q13 | 0.16 | 0.05 | 1.26×10−3 | 1.17 | 1.29 | 1.06 |
| rs9929218 | 16q22 | 0.13 | 0.03 | 3.16×10−5 | 1.14 | 1.21 | 1.07 |
| rs6983267 | 8q24 | 0.16 | 0.03 | 3.77×10−8 | 1.17 | 1.24 | 1.11 |
| rs4779584 | 15q23 | 0.15 | 0.03 | 2.35×10−5 | 1.16 | 1.24 | 1.08 |
| rs4939827 | 18q21 | 0.18 | 0.03 | 4.39×10−10 | 1.19 | 1.26 | 1.13 |
| rs3802842 | 11q23 | 0.19 | 0.03 | 1.89×10−10 | 1.21 | 1.29 | 1.14 |
| rs10795668 | 10p14 | 0.06 | 0.03 | 0.057 | 1.06 | 1.12 | 1.00 |
| rs16892766 | 8q23 | 0.24 | 0.05 | 7.41×10−7 | 1.27 | 1.40 | 1.16 |
| rs961253 | 20p12 | 0.15 | 0.03 | 6.35×10−7 | 1.16 | 1.23 | 1.09 |
| rs4444235 | 14q22 | 0.09 | 0.03 | 2.34×10−3 | 1.09 | 1.15 | 1.03 |
The anticipated effects of gender and age were blunted due to the case-control design for each study population but, because the datasets were very large and case-control matching was imprecise in most series (due to frequency matching), a significant effect on colorectal cancer risk was observed for age.