Table 1

Study characteristics

Study, year	Study no.	Country	Diagnostic modality	Diagnostic criteria	Endoscopists number	No. of experts	Patients analysed	Polyps analysed	No. of neoplasms/No. of non-neoplasms	Polyps, n (%) with high confidence predictions
Buchner et al (2010)17	1	USA	Exera	Kudo	2	2	75	41	25/16
Henry et al (2010)19	2	USA	Exera	Sano-Emura	1	1	52	126	67/59
Hirata et al (2007)69	3	Japan	Lucera	Brown hue	2	2	99	148	132/16
Ignjatovic et al (2009)20	4	UK	Lucera	Vascular pattern intensity	4	2	130	169	129/40	*
Lee et al (2011)21	5	South Korea	Lucera	Mucosal pattern and vascular density	1	1	142	156	80/76	125 (80.1%)
Machida et al (2004)23	6	Japan	Lucera	Kudo	2	2	34	43	34/9
Rastogi et al (2009)24	7	USA	Exera	Type A: HP	1	1	101	236	143/93
Rastogi et al (2009)24	7	USA	Exera	Type B: TA
Rastogi et al (2011)6	8	USA	Exera	Type A: HP	6	6	134	384	147/237
Rastogi et al (2011)6	8	USA	Exera	Type B: TA
Rex (2009)22	9	USA	Exera	Pre NICE*	1	1	136	451	230/221	368 (81.6%)
Rogart et al (2008)26	10	USA	Exera	Vascular density, modified Kudo	4	4	302	265	129/134
Rotondano et al (2011)27	11	Italy	Lucera	Kudo	3	3	94	281	141/140
Sakamoto et al (2012)28	12	Japan	Lucera	Sano	1	1	80	116	52/42
Sano et al (2009)29	13	Japan	Lucera	Sano	1	1	92	150	111/39
Shahid et al (2011)30	14	USA	Exera	Sano	1	1	65	130	58/72
Singh et al (2011)31	15	Australia	Exera	Sano	1	1	32	50	30/20	50 (100%)
Zhou et al (2011)32	16	China	Lucera	Kudo and Sano	1	1	118	109	67/42
Ren (2012)25	17	China	Exera	Yoshiki	1	1	75	116	52/42
Kuiper et al (2012)33	18	The Netherlands	Exera	Kudo	3	0	108	281	141/140	231 (82.2%)
Abstracts
Coe et al (2012)43	19	USA	Exera	NICE	6	6	300	260	152/108
Hewett and Rex (2010)36	20	USA	Exera	Pre NICE*	1	1	225	235	38/197
Kaltenbach et al (2011)38	21	USA	Exera	NICE	2	2	220	236	146/90	178 (75.4%)
Kaltenbach et al (2012)39	22	USA	Exera	NICE	5	5	311	338	233/105	246 (72.8%)
Matthew et al (2008)34	23	USA	Exera	Reported patterns	1	0	100	231	106/125
Occhipinti et al (2011)37	24	Italy	Exera	Kudo	5	5	93	220	120/100
Pohl et al (2012)40	25	USA	Exera	NICE	10	NR	608	948	528/420	770 (81.3%)
Radaelli et al (2011)41	26	Italy	Exera	NR	NR	all	197	354	233/121	354*
Ringold et al (2008)35	27	USA	Exera	‘Cerebriform’	4	4	55	93	56/37
Yague et al (2011)42	28	Spain	Exera	Vascular patterns	1	1	75	215	107/108

*Information on the number of polyps predicted with low confidence was not provided.
NICE, Narrow Band Imaging International Colorectal Endoscopic Classification. This classification system includes criteria on polyp colour, vessels and surface pattern; NR, not reported; Pre NICE, classification systems based on similar criteria that preceded NICE.