Metabolic status of conventional and donor mice after 16 weeks of HFD
| Body weight gain (g) | Final body weight (g) | Average food intake (g/day) | Liver weight (% of body weight) | Epididymal fat pads (% of body weight) | Fasting glycaemia (mg/dl) | Fasting insulinaemia (pg/ml) | HOMA-IR | MCP-1 (pg/ml) | TNF-α (pg/ml) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Conventional HFD mean | 15.3±3.3 | 39±3.9 | 4.8±0.3 | 4.65±0.21 | 5.02±0.17 | 164±39 | 1944±820 | 19.46±9.58 | 36.2±47.1 | 5.4±4.4 |
| Responder donor | 17.6 | 40.2 | 4.7 | 3.77 | 5.03 | 191 | 3673 | 42.94 | 199 | 13.1 |
| Non-responder donor | 15.7 | 39.4 | 5.1 | 4.38 | 4.49 | 90 | 2054 | 11.31 | 4 | 3.5 |
Data obtained from a cohort of 24 conventional mice, data are mean±SEM.
HFD, high-fat diet; HOMA-IR, homeostasis model assessment of insulin resistance; MCP-1, monocyte chemotactic protein 1.