Table 1

Metabolic status of conventional and donor mice after 16 weeks of HFD

Body weight gain (g)Final body weight (g)Average food intake (g/day)Liver weight (% of body weight)Epididymal fat pads (% of body weight)Fasting glycaemia (mg/dl)Fasting insulinaemia (pg/ml)HOMA-IRMCP-1 (pg/ml)TNF-α (pg/ml)
Conventional HFD mean15.3±3.339±3.94.8±0.34.65±0.215.02±0.17164±391944±82019.46±9.5836.2±47.15.4±4.4
Responder donor17.640.24.73.775.03191367342.9419913.1
Non-responder donor15.739.45.14.384.4990205411.3143.5
  • Data obtained from a cohort of 24 conventional mice, data are mean±SEM.

  • HFD, high-fat diet; HOMA-IR, homeostasis model assessment of insulin resistance; MCP-1, monocyte chemotactic protein 1.