All (n=116) | Surgery (n=29) | Prednisone (n=77) | Other* (n=10) | p Value (surgery vs prednisone) | |
---|---|---|---|---|---|
Age at diagnosis, median (range) | 66.2 (15–87) | 63.3 (33–76) | 67.0 (15–87) | 68.5 (35–79) | 0.07 |
Sex (M/F) | 93/23 | 21/8 | 64/13 | 8/2 | 0.22 |
Initial presenting symptom(s) | |||||
Obstructive jaundice | 75 (65) | 21 (72) | 52 (68) | 2 (20) | 0.63 |
Pancreatic mass | 48 (41) | 20 (69) | 24 (31) | 4 (40) | <0.01 |
Pancreatitis | 13 (11) | 0 | 11 (14) | 1 (10) | 0.03 |
Other† | 8 (7) | 0 | 7 (9) | 1 (10) | 0.09 |
Serum IgG4 status | |||||
IgG4 >ULN | 75/99 (76) | 7/14 (50) | 62/76 (82) | 6/9 (67) | 0.03 |
IgG4 >2×ULN | 41/96 (43) | 5/14 (36) | 32/74 (43) | 4/8 (50) | 0.36 |
Biliary involvement at presentation | |||||
Distal only | 54 (47) | 14 (48) | 35 (45) | 2 (20) | 0.80 |
Proximal | 39 (34) | 3 (10) | 31 (40) | 1 (10) | <0.01 |
Other organ involvement | 58 (50) | 7 (24) | 46 (60) | 5 (50) | <0.01 |
All values reported as n (%), unless otherwise indicated.
*This column includes data for patients initially treated conservatively or with RTX.
†Other disease presentations include: IgG4-related interstitial nephritis, IgG4-related lymphadenopathy, and pancreatic steatorrhoea.
RTX, rituximab; ULN, upper limit of normal.