Table 1

Treatment protocols used for steroid, immunomodulator and rituximab (RTX) therapy

Induction regimenTaperMaintenance
SteroidsPrednisone 40 mg daily×4 weeks5 mg/wk until discontinuedNone
ImmunomodulatorAzathioprine 2.0–2.5 mg/kg/day (alternate: 6-MP 1 mg/kg/day) (alternate: MMF 750–1000 mg twice daily)N/AContinue×12–18 months
RTX375 mg/m2 intravenous BSA weekly×4 weeks Coadminister: oral diphenhydramine 50 mg and oral paracetamol 1000 mg onceN/ARepeat infusions every 2–3 months×24 months (total of 8 additional doses)
  • 6-MP, 6-mercaptopurine; BSA, body surface area; MMF, mycophenolate mofetil.