Table 2

Effects of Nod2 genotype on gut bacterial composition

ComponentCumulative % explainedp ValueMultiple testing correction
116.890.770.89
229.380.260.99
336.010.111.62
440.870.920.99
545.470.680.85
650.000.970.97
754.070.560.94
857.980.310.78
961.160.310.92
1064.190.241.20
1167.050.580.87
1269.870.340.74
1372.400.120.93
1474.840.440.83
1577.040.580.79
  • p Values are calculated using the median values for WT (n=13) and KO (n=14) for animals in each cage (n=1–3 animals per cage) for a t test in which the null hypothesis is that host genotype has no effect on the distribution of the coordinate. The results for the first 15 coordinates of the Bray–Curtis analysis shown in figure 5 are depicted. The ‘Multiple Testing Correction’ column shows correction for multiple hypothesis testing (in this case testing 15 coordinates) using the Benjamini and Hochberg procedure. No components reach statistical significance (p<0.05) indicating that the null hypothesis is accepted for all components, suggesting that Nod2 genotype has minimal effect on gut bacterial composition.