Analyte (* log transformed analysis) | Borderline NASH | Definite NASH | ||||||
---|---|---|---|---|---|---|---|---|
Derivation | Validation | Derivation | Validation | |||||
NAS 0-2 n=50 (miR=26) | NAS 3-8 n=95 (miR=60) | NAS 0-2 n=25 | NAS 3-8 n=65 | NAS 0-4 n=107 (miR=64) | NAS 5-8 n=39 (miR=22) | NAS 0-4 n=62 | NAS 5-8 n=28 | |
sFas (pg/ml) | 5847 | 6491 (p = 0.022) | 5923 | 5653 (p=NS) | 6150 | 6604 (p=NS) | 5706 | 5777 (p=NS) |
CK18 M30* (U/L) | 132.43 | 182.81 (p = 0.007) | 179.47 | 275.23 (p = 0.001) | 146.55 | 223.36 (p = 0.001) | 212.86 | 331.59 (p < 0.001) |
CK18 M65* (U/L) | 140.93 | 231.21 (p = 0.001) | 167.92 | 351.4 (p < 0.001) | 168.66 | 291.74 (p = 0.001) | 239.88 | 422.67 (p = 0.003) |
HMGB1* (ng/ml) | 1.65 | 2.08 (p=NS) | 1.70 | 2.42 (p = 0.003) | 1.81 | 2.29 (p=NS) | 2.02 | 2.63 (p = 0.028) |
miR-122* (/let7d snRNA) | 10.57 | 15.58 (p = 0.028) | 7.71 | 12.32 (p = 0.002) | 12.77 | 17.54 (p=NS) | 9.71 | 13.61 (p = 0.018) |