P-21 activated kinase (PAK) overexpression in GI tumourigenesis
| PAK overexpression in GI tumourigenesis | |||||||
|---|---|---|---|---|---|---|---|
| Disease | Proliferation | Invasion | Metastasis | Reference | |||
| PAK1 | PAK4 | PAK1 | PAK4 | PAK1 | PAK4 | ||
| Colorectal cancer* | + | + | + | + | + | − | 14 74 91 92 110 111 113 |
| Gastric cancer* | + | − | + | − | + | + | 16 86 134–138 141 |
| Oesophageal squamous cell carcinoma* | − | − | − | − | + | − | 15 145 |
| Hepatocellular carcinoma* | + | − | + | − | − | − | 18 143 144 |
(+) investigated; (−) not investigated.
*PAK1 expression increases with advanced disease stage.