Prevalence of colorectal neoplasia* and advanced neoplasia* in the derivation cohort by risk factors
| All subjects | Colorectal neoplasia* n=627 | Advanced neoplasia* n=108 | |||
|---|---|---|---|---|---|
| Prevalence (%) | Prevalence (%) | p Value | Prevalence (%) | p Value | |
| Gender | |||||
| Male | 955 (47.8) | 362 (37.9) | <0.001 | 63 (6.6) | 0.024 |
| Female | 1045 (52.3) | 265 (25.4) | 45 (4.3) | ||
| Age, years | |||||
| 50–55 | 747 (37.4) | 187 (25.0) | <0.001 | 25 (3.3) | <0.001 |
| 56–60 | 642 (32.1) | 202 (31.5) | 29 (4.5) | ||
| 61–65 | 429 (21.5) | 155 (36.1) | 33 (7.7) | ||
| 66–70 | 182 (9.1) | 83 (45.6) | 21 (11.5) | ||
| Family history present for a first-degree relative | |||||
| Present | 280 (14.0) | 106 (37.9) | 0.011 | 22 (7.9) | 0.050 |
| Absent | 1720 (86.0) | 521 (30.3) | 86 (5.0) | ||
| Smoking | |||||
| Never | 1845 (92.3) | 555 (30.1) | <0.001 | 93 (5.0) | 0.014 |
| Current or past | 155 (7.8) | 72 (46.5) | 15 (9.7) | ||
| No | 1812 (90.6) | 553 (30.5) | 0.013 | 91 (5.0) | 0.020 |
| Yes | 188 (9.4) | 74 (39.4) | 17 (9.0) | ||
| Diabetes | |||||
| No | 1860 (93.0) | 565 (30.4) | 0.001 | 95 (5.1) | 0.035 |
| Yes | 140 (7.0) | 62 (44.3) | 13 (9.3) | ||
| BMI | |||||
| <25 | 1385 (69.3) | 393 (28.4) | 0.002 | 73 (5.3) | 0.701 |
| ≥25 (obesity) | 615 (30.8) | 234 (38.0) | 35 (5.7) | ||
| Hypertension | |||||
| No | 1510 (72.5) | 442 (29.3) | <0.001 | 69 (4.6) | 0.004 |
| Yes | 490 (24.5) | 185 (37.8) | 39 (8.0) | ||
| IHD/heart disease | |||||
| No | 1957 (97.9) | 610 (31.2) | 0.242 | 104 (5.3) | 0.289 |
| Yes | 43 (2.2) | 17 (39.5) | 4 (9.3) | ||
| COAD | |||||
| No | 1986 (99.3) | 624 (31.4) | 0.568 | 108 (5.4) | 1.000 |
| Yes | 14 (0.7) | 3 (21.4) | 0 (0) | ||
| Stroke | |||||
| No | 1987 (99.4) | 623 (31.4) | 1.000 | 108 (5.4) | 1.000 |
| Yes | 13 (0.7) | 4 (30.8) | 0 (0) | ||
| Cirrhosis | |||||
| No | 1996 (99.8) | 627 (31.4) | 0.316 | 108 (5.4) | 1.000 |
| Yes | 4 (0.2) | 0 (0) | 0 (0) | ||
| GERD | |||||
| No | 1891 (94.6) | 594 (31.4) | 0.804 | 100 (5.3) | 0.357 |
| Yes | 109 (5.4) | 33 (30.3) | 8 (7.3) | ||
| Use of non-steroidal anti-inflammatory drugs | |||||
| No | 1915 (95.8) | 606 (31.6) | 0.177 | 107 (5.6) | 0.085 |
| Yes | 85 (4.3) | 21 (24.7) | 1 (1.2) | ||
| Use of aspirin | |||||
| No | 1949 (97.5) | 608 (31.2) | 0.357 | 106 (5.4) | 1.000 |
| Yes | 51 (2.5) | 19 (37.3) | 2 (3.9) | ||
*Colorectal neoplasia include adenoma, advanced neoplasia and cancer. Advanced neoplasia is defined as colorectal cancer, or any colorectal adenoma which has a size of ≥10 mm in diameter, high-grade dysplasia, villous or tubulovillous histologic characteristics, or any combination thereof.
BMI, Body Mass Index; COAD, chronic obstructive airway disease; GERD, gastroesophageal reflux disease; IHD, ischaemic heart disease.