Baseline characteristics of intention-to-treat patients receiving besifovir 90 mg, besifovir 150 mg and entecavir 0.5 mg daily
| Parameter | Besifovir 90 mg (n=36) | Besifovir 150 mg (n=39) | Entecavir 0.5 mg (n=39) | p Value |
|---|---|---|---|---|
| Age | ||||
| Mean (±SD) | 41.72 (±10.42) | 40 (±10.46) | 41.28 (±11.61) | 0.77 |
| Median (range) | 43 (22, 59) | 38 (20, 59) | 44 (21, 62) | 0.78 |
| Male: female | 21 : 15 | 32 : 7 | 31: 8 | 0.04 |
| Body mass index | ||||
| Mean (±SD) | 23.89 (±3.35) | 24.72 (±4.06) | 23.53 (±2.75) | 0.34 |
| Median (range) | 23.63 (17.19, 32.03) | 24.27 (17.3, 37.09) | 24.02 (17.34, 28.33) | 0.55 |
| Genotype B: C | 3 : 32 | 7 : 31 | 11 : 28 | 0.10 |
| HBeAg (pos:neg) | 20 : 16 | 21 : 18 | 22 : 17 | 0.97 |
| HBV DNA(log10IU/mL) | ||||
| Mean (±SD) | 6.8 (±1.27) | 6.79 (±1.70) | 6.98 (±1.45) | 0.82 |
| Median (range) | 7 (3.64, 8.86) | 6.81 (2.29, 9.27) | 7.09 (2.82, 9.14) | 0.86 |
| ALT (U/L) | ||||
| Mean (±SD) | 127.89 (±81.45) | 140.15 (±97.3) | 141.85 (± 101.81) | 0.79 |
| Median (range) | 118 (34, 373) | 97 (34, 444) | 107 (37, 476) | 0.83 |
| GGT (U/L) | ||||
| Mean (±SD) | 54.83 (±31.04) | 72.87 (± 53.47) | 63.32 (±48.43) | 0.24 |
| Median (range) | 51 (14, 122) | 61.5 (11, 249) | 48 (16, 197) | 0.34 |
| Total bilirubin (mg/dL) | ||||
| Mean (±SD) | 0.76 (± 0.25) | 0.84 (± 0.32) | 0.81 (±0.3) | 0.45 |
| Median (range) | 0.7 (0.35, 1.52) | 0.78 (0.4, 1.7) | 0.76 (0.3, 1.58) | 0.55 |
| Albumin (g/L) | ||||
| Mean (±SD) | 4.38 (± 0.33) | 4.38 (± 0.23) | 4.37 (±0.27) | 0.10 |
| Median (range) | 4.4 (3.8, 5.1) | 4.3 (4, 5) | 4.3 (3.8, 4.9) | 0.10 |
| Creatinine phosphokinase (U/L) | ||||
| Mean (±SD) | 118.69 (± 75.76) | 116.69 (±80.49) | 124.97 (± 97.3) | 0.91 |
| Median (range) | 105.5 (41, 381) | 87 (27, 397) | 101 (42, 644) | 0.59 |
| Carnitine (μmol/L) | ||||
| Mean (±SD) | 54.59 (±7.4) | 55.49 (±9.38) | NA | 0.65 |
| Median (range) | 54.4 (37.7, 71.4) | 55.9 (34.4, 70) | NA | 0.45 |
| Phosphorus (mg/dL) | ||||
| Mean (±SD) | 7.96 (±3.53) | 8.30 (±3.65) | 7.59 (± 3.31) | 0.67 |
| Median (range) | 9.91 (2.41, 13.0) | 9.29 (2.17, 14.24) | 8.67 (2.57, 12.07) | 0.32 |
| Creatinine clearance | ||||
| Mean (±SD) | 95.22 (±20.29) | 107.92 (± 29.79) | 96.26 (±17.67) | 0.03 |
| Median (range) | 90.5 (62.9, 150.3) | 105.4 (61, 230.75) | 95.28 (65.4, 136.4) | 0.06 |
ALT, alanine aminotransferase; GGT, gamma glutamyltransferas; HBV, hepatitis B virus; NA, not applicable.