Table 5

Fibrin glue

StudyTypePatientsFUEndpoint
Grimaud et al117RCT778 weeks
37 months (median)
Clinical remission:
38% vs 16% placebo (p=0.04)
18%
Lindsey et al118RCT4212 weeksCessation of drainage:
Simple: 50% vs 100% fistulotomy (p=0.06)
Complex: 69% vs 13% seton±flap (p=0.003)
Witte et al119OL347 months (median)Fistula closure: 55%
Vitton et al120OL143 months
23 months (median)
Fistula closure: 71%
       57%
de Parades et al121OL304 weeks
12 months (median)
Fistula closure: 57%
       50%
Loungnarath et al122Retro13 (Crohn)26 months (median)Fistula closure: 31%
Zmora et al123Retro2412 months (mean)Fistulae closure: 33%
Sentovich124Retro2010 months (mean)Fistula closure: 85%
  • FU, follow-up; OL, open label; RCT, randomised controlled trial; Retro, retrospective.