Comparisons between patients with IBS with and without high C4c values (>8.0 mg/mol for men and >6.0 mg/mol for women)
| C4c high (n=30) | C4c normal/low (n=103) | p Value | |
|---|---|---|---|
| Age, years | 39.0 (13.3) | 34.2 (12.7) | 0.10 |
| 75SeHCAT, % | 23 (23) | 30 (18) | 0.08 |
| FGF19, pg/mL | 106.2 (66.2) | 150.8 (108.1) | 0.01 |
| Total cholesterol, mmol/L | 5.3 (1.5) | 5.2 (1.1) | 0.92 |
| Triglyceride, mmol/L | 1.7 (1.1) | 1.1 (0.6) | 0.004 |
| HDL-cholesterol, mmol/L | 1.5 (0.4) | 1.8 (0.5) | 0.002 |
| BMI, kg/m2 | 25.7(4.5) | 23.2 (3.9) | 0.003 |
| Stool frequency (stools/day) | 2.3 (1.4) | 2.1 (1.2) | 0.47 |
| Stool consistency (BSF score) | 4.0 (1.3) | 4.4 (1.1) | 0.12 |
| Colonic transit time, days | 1.8 (1.2) | 1.7 (1.2) | 0.85 |
| Rectal pain threshold, mm Hg | 39.6 (12.8) | 41.8 (13.1) | 0.57 |
| GSRS-IBS abdominal pain | 4.1 (1.5) | 4.3 (1.3) | 0.48 |
| GSRS-IBS bloating | 4.7 (1.4) | 4.5(1.4) | 0.62 |
| GSRS-IBS diarrhoea | 4.0 (1.4) | 3.9 (1.2) | 0.94 |
| GSRS-IBS constipation | 3.4 (1.9) | 2.5(1.7) | 0.02 |
| GSRS-IBS satiety | 2.9 (1.6) | 2.7 (1.6) | 0.61 |
Significant differences (p<0.05) shown with bold style. Mean (SD).
BMI, body mass index; BSF, Bristol Stool Form; C4, 7α-hydroxy-4-cholesten-3-one; C4c, C4 corrected for cholesterol; FGF19, fibroblast growth factor 19; GSRS-IBS, Gastrointestinal Symptom Rating Scale-IBS; 75SeHCAT, 75Se-labelled homocholic acid-taurine.