Preprandial and postprandial rectal sensitivity parameters in patients with IBS and healthy controls
| Patients with IBS | Controls | Group main effect | Meal main effect | |||
|---|---|---|---|---|---|---|
| Preprandial | Postprandial | Preprandial | Postprandial | |||
| Thresholds (mm Hg) | ||||||
| Pain | 34.2±13.2 | 31.5±13.2 | 53.1±11.3 | 51.5±12.8 | β=−19.4±2.2* | β=2.6±0.5† |
| F1.306=75.3 | F1.306=27.2 | |||||
| p<0.0001 | p<0.0001 | |||||
| Discomfort | 22.9±10.4 | 21.5±10.2 | 40.6±15.4 | 40.2±14.7 | β=−18.3±1.9* | β=1.3±0.4† |
| F1.306=94.2 | F1.306=10.9 | |||||
| p<0.0001 | p=0.001 | |||||
| Urge | 14.5±6.9 | 13.6±6.4 | 20.7±7.8 | 20.5±7.3 | β=−6.6±1.1* | β=0.8±0.3† |
| F1.306=36.0 | F1.306=6.7 | |||||
| p<0.0001 | p=0.01 | |||||
| Perceived intensity (VAS) | ||||||
| Pain | 33.0±22.8 | 33.6±24.1 | 13.7±18.6 | 14.4±22.6 | β=19.7±3.9* | β=−1.3±1.1† |
| F1.297=25.7 | F1.297=1.46 | |||||
| p<0.0001 | p=0.23 | |||||
| Unpleasantness | 67.8±19.8 | 64.3±20.7 | 52.6±20.2 | 44.5±20.8 | β=16.6±3.4* | β=5.2±1.1† |
| F1.299=24.3 | F1.299=24.4 | |||||
| p<0.0001 | p<0.0001 | |||||
| Viscerosomatic referral areas (cm2) | ||||||
| Pain | 5.3±6.0 | 6.4±7.0 | 1.4±2.6 | 2.4±6.4 | β=3.8±1.1* | β=−0.8±0.3† |
| F1.273=12.1 | F1.273=7.3 | |||||
| p=0.0006 | p=0.007 | |||||
| Non-painful sensations | 5.9±6.8 | 7.2±8.2 | 2.7±3.8 | 4.7±9.6 | β=3.0±1.2* | β=−1.1±0.4† |
| F1.297=6.5 | F1.297=7.9 | |||||
| p=0.01 | p=0.005 | |||||
Descriptive data (preprandial and postprandial average values and SDs in patients with IBS and healthy controls), as well as results of the mixed two-way ANOVA models are shown. The main effect of group tests the difference between groups (premeal and postmeal combined), whereas the main effect of meal tests the difference between premeal and postmeal (both groups combined). No significant group-by-meal interaction effect was found for any of the rectal sensitivity parameters, indicating that the sensitising effect of the meal did not differ between patients with IBS and controls.
Significant effects are shown in bold.
*This β coefficient represents the average difference between controls and patients with IBS over both measurements (preprandial and postprandial); reference category=controls.
†This β coefficient represents the average difference between the postprandial and preprandial measurement over both groups; reference category=postprandial.
VAS, visual analogue scale.