Comparison among Seattle protocol, AFI-targeted histology and three-biomarker panel on AFI+ areas
| Seattle protocol+histology | AFI+histology | AFI+biomarkers | p Value | |
|---|---|---|---|---|
| No. of HGD/EC missed | 1 | 2 | 1 | N/A |
| Sensitivity for HGD/EC | 95.8% | 91.7% | 95.8% | ns |
| Total no. of biopsies | 1385 | 169 | 310 | N/A |
| No of biopsies per patient | 12.4 | 1.5 | 2.8 | <0.001 |
| No of biopsies for every HGD/EC case diagnosed | 60.2 | 7.7 | 13.5 | N/A |
Seattle protocol includes all biopsies taken on HRE white light endoscopy (random + targeted on macroscopically visible abnormal areas). AFI+ histology includes biopsies taken on AFI+ areas, regardless of their appearance on HRE. AFI + biomarkers column includes only the biopsies from AFI+ areas processed for the three-biomarker panel.
AFI, autofluorescence imaging; EC, early cancer; HGD, high-grade dysplasia; HRE, high-resolution endoscopy.