Faecal pH, succinate, total and specific SCFA (µmol/g) on pooled 5-day faecal samples after following a habitual diet for 5 days and low FODMAP and typical Australian diets for 17–21 days in cross-over trial (n=33)
| Measure | Australian diet | Low FODMAP diet | p Value | Habitual diet |
|---|---|---|---|---|
| pH | 7.16 (7.02–7.30) | 7.37* (7.23–7.51) | 0.001 | 7.18 (7.07–7.31) |
| Succinate† | 0.03 (0.02–0.04) | 0.03 (0.02–0.03) | 0.178 | 0.03 (0.03–0.04) |
| Total SCFA | 74.7 (65.9–83.4) | 77.6 (68.8–86.5) | 0.208 | 84.0 (74.8–93.2) |
| Butyrate | 14.0 (11.8–16.2) | 13.5 (11.3–15.7) | 0.672 | 16.2 (13.7–18.6) |
| Propionate | 14.4 (12.4–16.4) | 15.2 (13.4–16.9) | 0.145 | 16.2 (14.0–18.2) |
| Acetate | 38.6 (34.1–43.1) | 40.9 (36.1–45.6) | 0.126 | 42.9 (38.2–47.6) |
| Isobutyrate | 2.01 (1.66–2.37) | 2.07 (1.69–2.45) | 0.836 | 2.13 (1.86–2.41) |
| Isovalerate | 3.15 (2.52–3.78) | 3.22 (2.54–3.91) | 0.857 | 3.37 (2.89–3.85) |
| Valerate | 2.25 (1.82–2.67) | 2.29 (1.90–2.69) | 0.974 | 2.54 (1.97–3.10) |
| Caproate‡ | 1.03 (0.64–1.42) | 1.13 (0.74–1.52) | 0.454 | 1.20 (0.85–1.55) |
Interventional diets were analysed by Wilcoxon matched-pairs signed rank test. Statistically significant differences are shown in bold and based upon p≤0.05 for faecal pH and p<0.006 for SCFA concentrations after Bonferroni correction. Differences between habitual diet and interventional diets are indicated with an asterisk.
*p=0.004 compared with habitual diet; Wilcoxon matched-pairs signed rank test.
†Due to difficulties in analysis for succinate, n=18.
‡Due to difficulties in analysis for caproate, n=15.
FODMAP, Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols; SCFA, short-chain fatty acid.