Univariate analyses | Multivariate analyses | Imputation analyses | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Model A n=265 (102 events) | Model B (final)* n=290 (116 events) | Model B (final) n=405 (169 events) | ||||||||||
HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value† | |
Age (per year) | 1.050 | 1.033 to 1.068 | <0.001 | 1.049 | 1.024 to 1.075 | <0.001 | 1.053 | 1.031 to 1.077 | <0.001 | 1.043 | 1.023 to 1.064 | <0.001 |
Men | 1.094 | 0.782 to 1.530 | 0.600 | 2.568 | 1.537 to 4.292 | <0.001 | 2.310 | 1.422 to 3.752 | 0.001 | 1.830 | 1.218 to 2.750 | 0.001 |
BMI (per kg/m2) | 0.987 | 0.945 to 1.030 | 0.540 | – | – | – | – | – | – | – | – | – |
AntiHBc positive | 0.984 | 0.708 to 1.366 | 0.921 | – | – | – | – | – | – | – | – | – |
Platelet count (per 10*109/L) | 0.871 | 0.840 to 0.903 | <0.001 | 0.760 | 0.665 to 0.870 | <0.001 | 0.754 | 0.666 to 0.853 | <0.001 | 0.817 | 0.712 to 0.937 | <0.001 |
Platelet count squared | – | – | – | 1.005 | 1.001 to 1.009 | 0.008 | 1.005 | 1.002 to 1.009 | 0.005 | 1.003 | 0.999 to 1.007 | 0.040 |
Albumin (per g/L) | 0.887 | 0.854 to 0.921 | <0.001 | 0.989 | 0.940 to 1.040 | 0.662 | – | – | – | – | – | – |
Bilirubin (per μmol/L) | 1.041 | 1.024 to 1.059 | <0.001 | 0.995 | 0.971 to 1.019 | 0.669 | – | – | – | – | – | – |
Log10 AST/ALT (per 0.1) | 1.477 | 1.329 to 1.642 | <0.001 | 1.469 | 1.262 to 1.710 | <0.001 | 1.431 | 1.259 to 1.626 | <0.001 | 1.393 | 1.235 to 1.571 | <0.001 |
HCV genotype 3 | 1.036 | 0.647 to 1.659 | 0.883 | 1.850 | 0.994 to 3.442 | 0.052 | 1.833 | 1.043 to 3.221 | 0.035 | 1.612 | 0.945 to 2.749 | 0.039 |
*The clinical disease progression risk score based on the regression coefficients of the variables in model B was represented by Rc=(5.2 * age in years) – (2.8 * platelet count per 109/L)+(0.00517 * (platelet count per 109/L)2)+(358.2 * log10(AST/ALT))+(83.7 for male patients)+(60.6 in case of HCV genotype 3).
†The p value is based on the maximum likelihood ratio test.
ALT, alanine aminotransferase; antiHBc, anti-hepatitis B core antigen; AST, aspartate aminotransferase; BMI, body mass index; HCV, hepatitis C virus.