Poisson regression analysis: risk of acute pancreatitis associated with simvastatin
| Parameter | Comparison | Risk ratio (95% confidence limit) | P value |
|---|---|---|---|
| Simvastatin use | Yes vs no | 0.29 (0.27, 0.31) | <0.0001 |
| Age, years | 30–39 vs 18–20 | 0.91 (0.82,0.99) | 0.04 |
| 40–49 vs 18–20 | 0.94 (0.86, 1.03) | 0.21 | |
| 50–59 vs 18–20 | 1.23 (1.11, 1.34) | <0.0001 | |
| 60–69 vs 18–20 | 1.69 (1.53,1.86) | <0.0001 | |
| 70+ vs 18–20 | 2.02 (1.82, 2.24) | <0.0001 | |
| Gender | Male vs female | 1.12 (1.07, 1.19) | <0.0001 |
| Race/ethnicity | |||
| Asian vs white | 0.98 (0.89, 1.09) | 0.73 | |
| Black vs white | 1.30 (1.20, 1.42) | <0.0001 | |
| Hispanic vs white | 1.19 (1.12, 1.26) | <0.0001 | |
| Other vs white | 0.17 (0.14, 0.21) | <0.0001 | |
| Hypertriglyceridaemia | Yes vs no | 12.5 (10.8, 14.5) | <0.0001 |
| Gallstone disease | Yes vs no | 23.2 (22.0, 24.5) | <0.0001 |
| Chronic alcohol use | Yes vs no | 4.85 (4.49, 5.23) | <0.0001 |
| Smoking | Ever vs never | 1.22 (1.16, 1.29) | 0.003 |
Acute pancreatitis defined by diagnosis code and serum lipase ≥three times normal.