Univariate HRs (95% CI) of quartiles of the three genes for a metachronous gastric cancer
| Quartile of DNA methylation level | p for trend | ||||
|---|---|---|---|---|---|
| Variable | Q1 (lowest) | Q2 | Q3 | Q4 (highest) | |
| No. of patients | 195 | 196 | 196 | 195 | |
| Authentic metachronous gastric cancers | |||||
| miR-124a-3 | |||||
| No. of events | 12 | 17 | 15 | 22 | |
| HR (95% CI) | 1 | 1.26 (0.60 to 2.65) | 1.17 (0.55 to 2.51) | 2.17 (1.07 to 4.41) | 0.041 |
| p Value | 0.53 | 0.68 | 0.032 | ||
| EMX1 | |||||
| No. of events | 12 | 17 | 16 | 21 | |
| HR (95% CI) | 1 | 1.47 (0.70 to 3.08) | 1.30 (0.62 to 2.76) | 2.03 (1.00 to 4.14) | 0.075 |
| p Value | 0.31 | 0.49 | 0.051 | ||
| NKX6-1 | |||||
| No. of events | 14 | 11 | 20 | 21 | |
| HR (95% CI) | 1 | 0.70 (0.32 to 1.54) | 1.31 (0.66 to 2.60) | 1.43 (0.73 to 2.82) | 0.11 |
| p Value | 0.37 | 0.44 | 0.30 | ||
| All metachronous gastric cancers | |||||
| miR-124a-3 | |||||
| No. of events | 16 | 20 | 21 | 24 | |
| HR (95% CI) | 1 | 1.13 (0.59 to 2.19) | 1.24 (0.65 to 2.38) | 1.71 (0.90 to 3.22) | 0.094 |
| p Value | 0.71 | 0.52 | 0.10 | ||
| EMX1 | |||||
| No. of events | 16 | 20 | 19 | 26 | |
| HR (95% CI) | 1 | 1.28 (0.66 to 2.48) | 1.16 (0.60 to 2.26) | 1.83 (0.98 to 3.42) | 0.080 |
| p Value | 0.46 | 0.66 | 0.058 | ||
| NKX6-1 | |||||
| No. of events | 18 | 16 | 24 | 23 | |
| HR (95% CI) | 1 | 0.81 (0.41 to 1.58) | 1.24 (0.67 to 2.29) | 1.23 (0.66 to 2.28) | 0.29 |
| p Value | 0.53 | 0.49 | 0.51 | ||
p values <0.05 are shown in bold type.