The number of patients’ siblings and controls observed in each of the four genotype relative risk (GRR) categories
| GRR categories, n (%) | Patients (n=22) | Siblings (n=21) | Controls (n=25) | p Values |
|---|---|---|---|---|
| High (GRR >4.185) | 3 (14) | 1 (5) | 0 (0) | Pat-con 0.045 Sib-con 0.046 Pat-sib 0.726 |
| Elevated (GRR 2.273–4.185) | 2 (9) | 3 (14) | 0 (0) | |
| Average (GRR 0.445–2.277) | 11 (50) | 12 (57) | 11 (44) | |
| Reduced (GRR <0.445) | 6 (27) | 5 (24) | 14 (56) |
Categorised GRR in patients with CD and siblings was significantly greater compared with controls. Genotyping was performed using the Illumina Infinium Immunochip as described in the methods.
CD, Crohn's disease.