Chr | Locus lead SNP | p Value | Effect | OR | SE | Minor allele | Major allele | MAF | HWE pval | N | Nearest gene |
---|---|---|---|---|---|---|---|---|---|---|---|
‘Serum lipase activity’ phenotype | |||||||||||
9 | rs8176693 | 2.92×10−19 | 0.0613 | – | 0.007 | T | C | 0.09 | 0.743 | 1444 | ABO (intronic) |
19 | rs632111 | 2.05×10−6 | 0.019 | – | 0.004 | G | A | 0.43 | 0.555 | 1444 | FUT2 (3‘-UTR) |
16 | rs889512 | 9.94×10−6 | −0.028 | – | 0.006 | G | C | 0.11 | 1 | 1444 | CTRB2 (5‘ near gene) |
‘High serum lipase activity’ phenotype | |||||||||||
9 | rs8176693 | 5.19×10−9 | 0.849 | 2.34 | 0.145 | T | C | 0.09 | 0.743 | 1444 | ABO (intronic) |
19 | rs632111 | 1.98×10−4 | 0.346 | 1.41 | 0.093 | G | A | 0.43 | 0.555 | 1444 | FUT2 (3‘-UTR) |
16 | rs889512 | 3.31×10−4 | −0.594 | 0.55 | 0.165 | G | C | 0.11 | 1 | 1444 | CTRB2 (5‘ near gene) |
Linear regression analysis was performed after adjustment for age, sex, alcohol consumption and smoking.
Chr, chromosome; Effect, effect strength (β) and direction of minor SNP allele; HWE pval: Hardy–Weinberg p value; MAF, minor allele frequency of the SNP in the analysed sample; N, sample size; P, p value of association between locus lead SNP and phenotype.