Table 1

Lead SNP associations from the discovery-stage Study-of-Health-in-Pomerania-Genome-wide association studies (GWAS) on the phenotypes ‘Serum lipase activity’ and ‘High serum lipase activity’

Chr	Locus lead SNP	p Value	Effect	OR	SE	Minor allele	Major allele	MAF	HWE pval	N	Nearest gene
‘Serum lipase activity’ phenotype
9	rs8176693	1.29×10⁻³⁰	0.139	−	0.012	T	C	0.1	0.851	3966	ABO (intronic)
19	rs632111	6.15×10⁻⁹	0.04	−	0.007	G	A	0.43	0.041	3966	FUT2 (3‘-UTR)
16	rs889512	1.91×10⁻⁸	−0.063	−	0.011	G	C	0.11	0.575	3966	CTRB2 (5‘ near gene)
‘High serum lipase activity’ phenotype
9	rs8176693	1.28×10⁻²²	0.819	2.27	0.084	T	C	0.1	0.851	3966	ABO (intronic)
19	rs632111	5.72×10−⁹	0.306	1.36	0.053	G	A	0.43	0.041	3966	FUT2 (3‘-UTR)
16	rs889512	6.41×10⁻⁴	−0.322	0.72	0.094	G	C	0.11	0.575	3966	CTRB2 (5‘ near gene)

Chr, chromosome; Effect, effect strength (β) and direction of minor SNP allele; HWE pval, Hardy–Weinberg p value; MAF, minor allele frequency; N, sample size; P, p value of association between locus lead SNP and phenotype; genomic control was applied for the ‘serum lipase activity’ analysis only.