Table 4

Univariate HRs (95% CI) of known and potential risk factors for metachronous gastric cancer

Authentic metachronous gastric cancersAll metachronous gastric cancers
VariableNo. of eventsHRp ValueNo. of eventsHRp Value
Hospital
 NCC521591
 TYU61.03 (0.44 to 2.40)0.95101.43 (0.73 to 2.80)0.30
 WMU81.77 (0.84 to 3.73)0.14122.26 (1.21 to 4.21)0.01
Age
 ≥70271341
 <5043.50 (1.23 to 10.0)0.01942.76 (0.98 to 7.79)0.055
 50–5960.58 (0.24 to 1.39)0.2290.71 (0.34 to 1.48)0.36
 60–69290.91 (0.54 to 1.54)0.72340.86 (0.54 to 1.39)0.55
Gender
 Male601741
 Female60.43 (0.19 to 1.00)0.04970.41 (0.19 to 0.89)0.023
Pepsinogen index
 (−)281351
 (+)52.18 (0.83 to 5.68)0.1161.88 (0.79 to 4.50)0.15
 (2+)161.65 (0.89 to 3.06)0.11181.44 (0.82 to 2.55)0.21
 (3+)171.56 (0.85 to 2.87)0.15221.54 (0.90 to 2.63)0.12
H. pylori infection before the enrolment
 Positive411311
 Negative251.02 (0.61 to 1.71)0.94500.93 (0.58 to 1.47)0.74
Past history of ER (times)
 0131161
 1431.18 (0.63 to 2.19)0.6491.10 (0.63 to 1.93)0.74
 250.81 (0.29 to 2.29)0.69101.38 (0.62 to 3.04)0.43
 355.66 (2.01 to 15.9)0.00165.46 (2.13 to 14.0)0.0004
Smoking (pack-years)
 0151181
 1–39171.17 (0.57 to 2.40)0.66251.55 (0.85 to 2.83)0.15
 ≥40292.24 (1.27 to 3.96)0.006322.06 (1.21 to 3.50)0.007
Green vegetable intake (per week)
 ≤2 days201251
 3–4 days250.67 (0.37 to 1.21)0.18320.69 (0.41 to 1.16)0.16
 Almost daily180.65 (0.34 to 1.23)0.18200.57 (0.32 to 1.02)0.06
  • p values <0.05 are shown in bold type.

  • ER, endoscopic resection; NCC, National Cancer Center Hospital; TYU, Tokyo University Hospital; WMU, Wakayama Medical University Hospital.