International Club of Ascites (ICA-AKI) new definitions for the diagnosis and management of AKI in patients with cirrhosis
| Subject | Definition | ||
|---|---|---|---|
| Baseline sCr | A value of sCr obtained in the previous 3 months, when available, can be used as baseline sCr. In patients with more than one value within the previous 3 months, the value closest to the admission time to the hospital should be used In patients without a previous sCr value, the sCr on admission should be used as baseline | ||
| Definition of AKI | Increase in sCr ≥0.3 mg/dL (≥26.5 µmol/L) within 48 h; ora percentage increase sCr ≥50% from baseline which is known, or presumed, to have occurred within the prior 7 days | ||
| Staging of AKI | Stage 1: increase in sCr ≥0.3 mg/dL (26.5 µmol/L) or an increase in sCr ≥1.5-fold to twofold from baseline Stage 2: increase in sCr >two to threefold from baseline Stage 3: increase of sCr >threefold from baseline or sCr ≥4.0 mg/dL (353.6 µmol/L) with an acute increase ≥0.3 mg/dL (26.5 µmol/L) or initiation of renal replacement therapy | ||
| Progression of AKI | Progression | Regression | |
| Progression of AKI to a higher stage and/or need for RRT | Regression of AKI to a lower stage | ||
| Response to treatment | No response | Partial response | Full response |
| No regression of AKI | Regression of AKI stage with a reduction of sCr to ≥0.3 mg/dL (26.5 µmol/L) above the baseline value | Return of sCr to a value within 0.3 mg/dL (26.5 µmol/L) of the baseline value | |
AKI, acute kidney injury; RRT, renal replacement therapy; sCr, serum creatinine.