Table 2

International Club of Ascites (ICA-AKI) new definitions for the diagnosis and management of AKI in patients with cirrhosis

Baseline sCrA value of sCr obtained in the previous 3 months, when available, can be used as baseline sCr. In patients with more than one value within the previous 3 months, the value closest to the admission time to the hospital should be used
In patients without a previous sCr value, the sCr on admission should be used as baseline
Definition of AKIIncrease in sCr ≥0.3 mg/dL (≥26.5 µmol/L) within 48 h; ora percentage increase sCr ≥50% from baseline which is known, or presumed, to have occurred within the prior 7 days
Staging of AKIStage 1: increase in sCr ≥0.3 mg/dL (26.5 µmol/L) or an increase in sCr ≥1.5-fold to twofold from baseline
Stage 2: increase in sCr >two to threefold from baseline
Stage 3: increase of sCr >threefold from baseline or sCr ≥4.0 mg/dL (353.6 µmol/L) with an acute increase ≥0.3 mg/dL (26.5 µmol/L) or initiation of renal replacement therapy
Progression of AKIProgressionRegression
Progression of AKI to a higher stage and/or need for RRTRegression of AKI to a lower stage
Response to treatmentNo responsePartial responseFull response
No regression of AKIRegression of AKI stage with a reduction of sCr to ≥0.3 mg/dL (26.5 µmol/L) above the baseline valueReturn of sCr to a value within 0.3 mg/dL (26.5 µmol/L) of the baseline value
  • AKI, acute kidney injury; RRT, renal replacement therapy; sCr, serum creatinine.