Table 4

Association results of Genome-wide association studies (GWAS) top SNPs in the pancreatitis cohort vs healthy blood donors

Model	Additive genetic model			Recessive genetic model
Model	PVAL	OR	95% CI	PVAL	OR	95% CI
rs632111 (FUT2 GWAS lead SNP)
Pan vs BD	0.054	1.12	1.00 to 1.26	0.046	1.23	1.00 to 1.51
CP vs BD	0.003	1.24	1.08 to 1.44	2.4×10⁻⁴	1.58	1.24 to2.02
AP vs BD	0.999	1	0.86 to 1.16	0.469	0.9	0.68 to 1.19
ICP vs BD	0.017	1.27	1.04 to 1.55	0.001	1.72	1.25 to 2.38
ACP vs BD	0.497	1.08	0.87 to 1.34	0.276	1.23	0.85 to1.79
rs601338 (W134X SNP)
Pan vs BD	0.047	1.12	1.00 to 1.26	0.031	1.26	1.02 to 1.56
CP vs BD	0.015	1.2	1.03 to 1.38	0.001	1.57	1.22 to 2.02
AP vs BD	0.501	1.05	0.91 to 1.22	0.839	0.97	0.73 to 1.29
ICP vs BD	0.081	1.2	0.98 to 1.46	0.003	1.7	1.21 to 2.37
ACP vs BD	0.592	1.06	0.85 to 1.32	0.168	1.32	0.90 to 1.93
rs889512 (CTRB2 locus lead SNP)
Pan vs BD	0.809	0.9	0.81 to 1.18	0.974	0.99	0.46 to 2.12
CP vs BD	0.830	0.98	0.77 to 1.23	0.647	1.23	0.51 to 2.99
AP vs BD	0.868	0.98	0.77 to 1.24	0.564	0.73	0.25 to 2.19
ICP vs BD	0.757	1.05	0.77 to 1.44	0.720	0.77	0.18 to 3.36
ACP vs BD	0.073	0.71	0.48 to 1.05	0.902	0.91	0.21 to 3.98

ACP, alcoholic chronic pancreatitis; AP, acute pancreatitis; BD, blood donor cohort; CP, chronic pancreatitis; ICP, Idiopathic chronic pancreatitis; Pan, total pancreatitis cohort; PVAL, p value (χ² test); 95% CI, 95% CI of OR, grey shaded cells are nominal significant (PVAL<0.05) yellow shaded cells are significant after Bonferroni correction for 15 tests (PVAL<0.05/15=0.003) and red shaded cells are significant after Bonferroni correction for 30 tests (PVAL<0.05/30=0.0017). Genotyping of SNPs was performed by TaqMan analysis or genomic sequencing.