Association results (A) and comparison (B) of extreme groups in the pancreatitis cohort vs healthy blood donors
| BD | Pan | CP | AP | ICP | ACP | |
|---|---|---|---|---|---|---|
| (A) | ||||||
| Blood group B (G1) vs remaining (G0) | ||||||
| G1 | 180 | 171 | 100 | 71 | 40 | 39 |
| G0 | 1311 | 871 | 437 | 434 | 189 | 175 |
| Non-secretor (G1) vs secretor (G0) | ||||||
| G1 | 233 | 186 | 113 | 73 | 54 | 38 |
| G0 | 1258 | 795 | 389 | 406 | 172 | 156 |
| Blood group B and non-secretor (G1) vs remaining (G0) | ||||||
| G1 | 30 | 25 | 17 | 8 | 6 | 6 |
| G0 | 1461 | 956 | 485 | 471 | 220 | 188 |
| Blood group B vs non-B | Non-secretor vs secretor | Blood group B and non-secretor vs remaining | ||||
|---|---|---|---|---|---|---|
| PVAL | OR (95% CI) | PVAL | OR (95% CI) | PVAL | OR (95% CI) | |
| (B) | ||||||
| Pan vs BD | 0.0023 | 1.43 (1.14 to 1.79) | 0.0352 | 1.26 (1.02 to 1.56) | 0.4562 | 1.27 (0.74 to 2.18) |
| CP vs BD | 2.2×10−4 | 1.67 (1.28 to 2.18) | 7.2×10−7 | 1.57 (1.22 to 2.02) | 0.1129 | 1.71 (0.93 to 3.12) |
| AP vs BD | 0.2774 | 1.19 (0.89 to 1.6) | 0.8958 | 0.97 (0.73 to 1.29) | 0.7776 | 0.83 (0.38 to 1.82) |
| ICP vs BD | 0.0300 | 1.54 (1.06 to 2.24) | 0.0026 | 1.70 (1.21 to 2.379) | 0.7044 | 1.33 (0.55 to 3.23) |
| ACP vs BD | 0.0161 | 1.26 (1.11 to 2.37) | 0.1907 | 1.32 (0.9 to 1.93) | 0.4744 | 1.55 (0.64 to 3.78) |
ACP, alcoholic chronic pancreatitis; AP, acute pancreatitis; BD, blood donor cohort; CP, chronic pancreatitis; ICP, idiopathic chronic pancreatitis; Pan, total pancreatitis cohort; PVAL, p value (χ2 test).
95% CI, 95% CI of OR, grey shaded cells are nominal significant (PVAL<0.05) and red shaded cells are significant after Bonferroni correction for 15 tests (PVAL<0.05/15 = 0.003). Genotyping of SNPs was performed by TaqMan analysis or genomic sequencing.