Table 4

An optimised logistic regression model (incorporating HLA Class I, IFNL3 and KIR) predicting viral clearance

Explanatory VariablesOR (95% CIs)p Value
A*030.42 (0.23 to 0.76)0.005
B*150.12 (0.03 to 0.52)0.004
C*010.13 (0.03 to 0.5)0.003
C*0910.74 (1.42 to 81.3)0.022
C*120.31 (0.11 to 0.86)0.024
IFNL3 CC versus CT/TT0.11 (0.06 to 0.19)<0.001
KIR2DS33.45 (1.77 to 6.72)<0.001
  • The explanatory variables are selected by forward and reverse stepwise selection minimising Akaike Information Criteria. OR, CIs and p values are presented. The dataset consists of patients from the Irish cohort who have had their HLA Class I genotype determined (n=319).

  • IFNL3 CC, protective genotype; IFNL3 CT/TT, deleterious genotype.