An optimised logistic regression model (incorporating HLA Class I, IFNL3 and KIR) predicting viral clearance
| Explanatory Variables | OR (95% CIs) | p Value |
|---|---|---|
| A*03 | 0.42 (0.23 to 0.76) | 0.005 |
| B*15 | 0.12 (0.03 to 0.52) | 0.004 |
| C*01 | 0.13 (0.03 to 0.5) | 0.003 |
| C*09 | 10.74 (1.42 to 81.3) | 0.022 |
| C*12 | 0.31 (0.11 to 0.86) | 0.024 |
| IFNL3 CC versus CT/TT | 0.11 (0.06 to 0.19) | <0.001 |
| KIR2DS3 | 3.45 (1.77 to 6.72) | <0.001 |
The explanatory variables are selected by forward and reverse stepwise selection minimising Akaike Information Criteria. OR, CIs and p values are presented. The dataset consists of patients from the Irish cohort who have had their HLA Class I genotype determined (n=319).
IFNL3 CC, protective genotype; IFNL3 CT/TT, deleterious genotype.