Multivariate Cox regression analysis of variables associated with death after listing for liver transplantation in all patients with refractory ascites
| Cox regression analysis | Competing risk Cox regression analysis | |||||
|---|---|---|---|---|---|---|
| Outcome death (censored at transplant) | Outcome death | |||||
| HR | 95% CI | p Value | HR | 95% CI | p Value | |
| MELD score | 1.11 | 1.01 to 1.21 | 0.024 | 0.99 | 0.92 to 1.06 | 0.723 |
| Hyponatraemia | 2.45 | 1.07 to 5.64 | 0.035 | 1.39 | 0.68 to 2.82 | 0.367 |
| Hepatocellular carcinoma | 0.32 | 0.07 to 1.46 | 0.141 | 0.80 | 0.27 to 2.40 | 0.689 |
| Previous variceal haemorrhage | 0.50 | 0.17 to 1.40 | 0.186 | 0.51 | 0.22 to 1.18 | 0.116 |
| Prophylactic antibiotics | 0.64 | 0.27 to 1.56 | 0.329 | 0.39 | 0.17 to 0.90 | 0.027 |
| NSBB | 0.46 | 0.32 to 0.98 | 0.045 | 0.49 | 0.25 to 0.96 | 0.038 |
p Value in bold indicates statistical significance.
In the competing risk Cox regression analysis, the only variable associated with the outcome transplant was MELD (adjusted HR 1.10; 95% CI 1.04 to 1.17, p=0.001) (model not shown).
Reference group (relative risk 1.00): no hyponatraemia, no hepatocellular carcinoma, no previous variceal haemorrhage, no prophylactic antibiotics and no NSBB.
MELD, model for end-stage liver disease; NSBB, non-selective β-blockers.