Clinical, histological and pathological data of 86 HBV- and 90 non-HBV-related HCC
| HBV positive HCC | HBV negative HCC | p Value | |
|---|---|---|---|
| Gender | |||
| Male | 80% (69/86) | 81% (73/90) | NS |
| Female | 20% (17/86) | 19% (17/90) | |
| Age (year) | |||
| Means±SD | 53.3±12.4 | 65±9.8 | <0.0001* |
| Geographic origins | |||
| Africans | 45% (39/86) | 5% (4/90) | <0.0001** |
| Asians | 18% (15/86) | 0 (0/90) | |
| Europeans | 37% (36/86) | 95% (86/90) | |
| Cofactors/aetiologies | |||
| HDV | 5% (4/86) | 0 (0/90) | NS |
| HCV | 9% (8/86) | 23% (21/90) | 0.01** |
| Alcohol | 10% (9/86) | 40% (36/90) | <0.0001** |
| Non-alcoholic steato-hepatitis | 2% (2/86) | 4% (4/90) | NS |
| Haemochromatosis | 0 (0/86) | 7% (6/90) | NS |
| Others | 0 (0/86) | 26% (23/90) | NS |
| α-Fetoprotein (ng/mL) | |||
| Means±SD | 15 026±48 569 | 2455±9265 | 0.008* |
| Tumour size (mm) | |||
| Means±SD | 72.7±49.6 | 77.1±52.6 | 0.03* |
| Edmondson grade | |||
| Well differentiated (I–II) | 38% (33/86) | 53% (48/90) | 0.05** |
| Poorly differentiated (III–IV) | 58% (50/86) | 45% (40/90) | |
| Unknown | 4% (3/86) | 2% (2/90) | |
| Portal invasions | |||
| Yes | 20% (17/86) | 16% (14/90) | |
| No | 79% (68/86) | 83% (75/90) | NS |
| Unknown | 1% (1/86) | 1% (1/90) | |
| Microvascular invasions | |||
| Yes | 43% (37/86) | 56% (50/90) | |
| No | 55% (47/86) | 43% (39/90) | NS |
| Unknown | 2% (2/86) | 1% (1/90) | |
| Satellite nodules | |||
| Yes | 48% (41/86) | 49% (44/90) | |
| No | 50% (43/86) | 51% (46/90) | NS |
| Unknown | 2% (2/86) | 0 (0/90) | |
| Early relapse (<24 month) | |||
| No | 36% (31/86) | 37% (33/90) | |
| Yes | 43% (37/86) | 60% (54/90) | NS |
| Unknown | 21% (18/86) | 3% (3/90) | |
p Values obtained from Mann–Whitney (*) and χ2 (**) tests based on the given clinical variable are shown.
HCC, hepatocellular carcinoma; HDV, hepatitis D virus.