Chimpanzees | Macaques | Tupaia belangeri | HuHep mice | His-HuHep mice | Ad-HBV or AAV-HBV mice | |
---|---|---|---|---|---|---|
HBV entry | + | ? | + | + | + | − |
HBV production | + | + | + | + | + | + |
cccDNA establishment | + | ? | + | + | + | − |
Chronic HBV infection | − | ? | + | + | ? | + |
HCC development | − | ? | ? | ? | ? | ? |
Adaptive immune responses | + | ? | ? | − | + | + |
HBV tolerance | − | ? | ? | − | + | + |
Antiviral drug testing | + | ? | + | + | + | + |
Therapeutic vaccine development | + | ? | ? | − | + | + |
cccDNA, covalently closed circular DNA; HCC, hepatocellular carcinoma.