Table 1

Allele frequency of the variants analysed in this study

SubjectsSexnPRSS1PRSS2 (rs10273639, T/C)RIPPLY1 (rs7057398, C/T)MORC4 (rs12688220, C/T)
T allelep ValueOR (95% CI)C allelep ValueOR (95% CI)T allelep ValueOR (95% CI)
ACPM24566.9%0.00010.57 (0.43 to 0.76)68.6%4.2×10−8 2.78 (1.90 to 4.08)58.0%3.7×10−7 2.56 (1.76 to 3.72)
F2772.2%0.390.75 (0.39 to 1.47)53.7%0.081.68 (0.94 to 2.98)46.3%0.0311.92 (1.08 to 3.48)
ICPM9767.5%0.00590.59 (0.40 to 0.86)61.9%0.0042.07 (1.26 to 3.42)51.5%0.0071.98 (1.20 to 3.20)
F10071.5%0.100.73 (0.50 to 1.06)55.5%0.00051.81 (1.28 to 2.54)44.5%0.0011.78 (1.26 to 2.53)
ControlsM24678.0%43.9%35.0%
F23477.6%40.8%31.0%
  • p Values were determined versus controls by Fisher’s exact test.

  • ACP, alcoholic chronic pancreatitis; F, female; ICP, idiopathic chronic pancreatitis; M, male; n, number of subjects.