Table 6

Multivariate Cox regression analysis of variables associated with death after listing for liver transplantation in PRS-matched patients with refractory ascites

Cox regression analysisCompeting risk Cox regression analysis
Outcome death (censored at transplant)Outcome death
HR95% CIp ValueHR95% CIp Value
MELD score1.070.97 to 1.190.1970.980.90 to 1.060.600
Hyponatraemia2.700.84 to 8.670.0951.320.50 to 3.520.579
Previous variceal haemorrhage0.690.18 to 2.640.5900.450.12 to 1.650.229
Prophylactic antibiotics0.600.19 to 1.950.3950.390.14 to 1.080.070
NSBB0.330.12 to 0.890.0280.350.14 to 0.860.022
  • p Value in bold indicates statistical significance.

  • In the competing risk Cox regression analysis, the only variable associated with the outcome transplant was MELD (adjusted HR 1.12; 95% CI 1.04 to 1.20, p=0.002) (model not shown). Hepatocellular carcinoma excluded from the analysis because of small number of patients (n=3).

  • Reference group (relative risk 1.00): no hyponatraemia, no previous variceal haemorrhage, no prophylactic antibiotics and no NSBB.

  • MELD, model for end-stage liver disease; NSBB, non-selective β-blockers; PRS, propensity risk score.