Multivariate Cox regression analysis of variables associated with death after listing for liver transplantation in PRS-matched patients with ascites
| Cox regression analysis | Competing risk Cox regression analysis | |||||
|---|---|---|---|---|---|---|
| Outcome death (censored at transplant) | Outcome death | Outcome transplant | ||||
| HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| MELD score | 1.08 (1.02 to 1.15) | 0.006 | 1.00 (0.95 to 1.06) | 0.992 | 1.05 (1.01 to 1.08) | 0.007 |
| Hyponatraemia | 3.94 (2.10 to 7.39) | <0.001 | 2.08 (1.19 to 3.63) | 0.010 | 0.84 (0.59 to 1.20) | 0.341 |
| Hepatocellular carcinoma | 0.58 (0.17 to 1.92) | 0.368 | 0.46 (0.14 to 1.54) | 0.205 | 1.81 (1.16 to 2.83) | 0.009 |
| Previous variceal haemorrhage | 0.89 (0.46 to 1.74) | 0.731 | 0.74 (0.37 to 1.46) | 0.382 | 1.16 (0.81 to 1.67) | 0.418 |
| Prophylactic antibiotics | 0.52 (0.23 to 1.16) | 0.109 | 0.42 (0.19 to 0.90) | 0.027 | 1.61 (1.13 to 2.29) | 0.008 |
| NSBB | 0.47 (0.26 to 0.83) | 0.009 | 0.55 (0.32 to 0.95) | 0.032 | 1.42 (1.01 to 1.99) | 0.041 |
p Value in bold indicates statistical significance.
Reference group (relative risk 1.00): no hyponatraemia, no hepatocellular carcinoma, no previous variceal haemorrhage, no prophylactic antibiotics and no NSBB.
MELD, model for end-stage liver disease; NSBB, non-selective β-blockers; PRS, propensity risk score.