Table 4

Multivariate Cox regression analysis of variables associated with death after listing for liver transplantation in PRS-matched patients with ascites

 Cox regression analysisCompeting risk Cox regression analysis
Outcome death (censored at transplant)Outcome deathOutcome transplant
HR (95% CI)p ValueHR (95% CI)p ValueHR (95% CI)p Value
MELD score1.08 (1.02 to 1.15)0.0061.00 (0.95 to 1.06)0.9921.05 (1.01 to 1.08)0.007
Hyponatraemia3.94 (2.10 to 7.39)<0.0012.08 (1.19 to 3.63)0.0100.84 (0.59 to 1.20)0.341
Hepatocellular carcinoma0.58 (0.17 to 1.92)0.3680.46 (0.14 to 1.54)0.2051.81 (1.16 to 2.83)0.009
Previous variceal haemorrhage0.89 (0.46 to 1.74)0.7310.74 (0.37 to 1.46)0.3821.16 (0.81 to 1.67)0.418
Prophylactic antibiotics0.52 (0.23 to 1.16)0.1090.42 (0.19 to 0.90)0.0271.61 (1.13 to 2.29)0.008
NSBB0.47 (0.26 to 0.83)0.0090.55 (0.32 to 0.95)0.0321.42 (1.01 to 1.99)0.041
  • p Value in bold indicates statistical significance.

  • Reference group (relative risk 1.00): no hyponatraemia, no hepatocellular carcinoma, no previous variceal haemorrhage, no prophylactic antibiotics and no NSBB.

  • MELD, model for end-stage liver disease; NSBB, non-selective β-blockers; PRS, propensity risk score.