Table 3

Correlation between clinical parameters and biological markers of humoral activity (GLT and IGH expression in jejunal mucosa, IgG in the lumen and mucosal IgG⁺ cells) in H and IBS-D participants

	Bowel movements		Stool form		Depression level
GLT	H (n=10–13)	IBS-D (n=9–16)	H (n=10–14)	IBS-D (n=9–16)	H (n=10)	IBS-D (n=9–16)
	r_s	p Value	r_s	p Value	r_s	p Value
μGLT	0.48	0.008*	0.55	0.002**	0.22	0.256
γ3GLT	0.43	0.019*	0.42	0.019*	0.35	0.062
γ1GLT	0.56	0.004*	0.51	0.009*	0.41	0.049
αGLT	0.17	0.632	0.71	0.018*	0.33	0.327
γ2GLT	0.75	0.019*	0.71	0.038	0.50	0.204
γ4GLT	0.41	0.184	0.49	0.091	0.34	0.261
εGLT	−0.02	0.920	0.16	0.466	0.46	0.022

IGH	H (n=13)	IBS-D (n=16)	H (n=14)	IBS-D (n=16)	H (n=13)	IBS-D (n=16)

IGHM	0.27	0.181	0.06	0.744	0.13	0.497
IGHG3	0.37	0.045	0.45	0.013*	0.44	0.016
IGHG1	0.59	<0.001***	0.68	<0.0001***	0.59	<0.001***
IGHA	0.32	0.085	0.36	0.048	0.54	0.002**
IGHG2	0.39	0.037	0.42	0.020*	0.43	0.023
IGHG4	0.60	<0.001***	0.67	<0.0001***	0.45	0.015*
IGHE	0.55	0.002**	0.43	0.018*	0.39	0.042

Luminal Ig	H (n=10)	IBS-D (n=11)	H (n=10)	IBS-D (n=11)	H (n=10)	IBS-D (n=15)

IgG	0.50	0.026*	0.39	0.086	0.20	0.364

Ig⁺cells	H (n=6)	IBS-D (n=7)	H (n=6)	IBS-D (n=7)	H (n=6)	IBS-D (n=7)

IgG⁺	0.54	0.055	0.65	0.015*	0.35	0.221

p Values considered significant are shown in bold (see online supplementary figure 3). p Value adjusted (false discovery rate): *<0.05; **<0.01 and ***<0.001.
GLT, germline transcript; H, healthy subjects; IBS-D, diarrhoea-predominant IBS; Ig, immunoglobulin; IGH, Ig heavy chain.