Table 1

Test performance per screening test in asymptomatic, average-risk adults

Sensitivity (%) for detecting advanced neoplasia9 to 2443–4832 to 5343 44 47 4990 to 92*508835 to 974388 to 9851
Sensitivity (%) for detecting CRC13 to 5044–4679 5290 to 92*50100†5392 to 9950
Reduction in CRC incidence (%) intention-to-screenNo‡19 54Unknown1854Unknown69§55
Reduction in CRC mortality (%) intention-to-screen14 to 161922¶252854Unknown68§55
  • *Sensitivity is given for the distal colon.

  • †No CRCs were missed by CTC in six screening trials.

  • ‡No reduction in incidence was found in three of four RCTs included in meta-analysis.

  • § Meta-analysis of observational studies, more results expected.

  • ¶ Ecological study.

  • CRC, colorectal cancer; CTC, CT colonography; FIT, faecal immunochemical test for haemoglobin; FS, flexible sigmoidoscopy; gFOBT, guaiac faecal occult blood test; RCT, randomised controlled trial.