Table 1

Fifteen significantly differentially expressed proteins identified by the SAM and PAM analyses

				HBV-ACLF vs CHB		HBV-ACLF vs normal
Cytokine	Gene symbol	Entrez GeneID	Full name	Fold change	q Value	Fold change	q Value
HGF*†	HGF	3082	Hepatocyte growth factor (hepapoietin A, scatter factor)	35.5	0.0097	34.2	0.0007
MIP-3α*†	CCL20	6364	MIP-3α	9.1	0.0078	8.2	0.0007
CEACAM1*†	CEACAM1	634	Carcinoembryonic antigen-related cell adhesion molecule 1	5.6	0.0136	4.7	0.0012
GDF-15*†	GDF15	9518	Growth differentiation factor 15	5.2	0.0052	3.0	0.0007
E-selectin*†	SELE	6401	Selectin E	4.9	0.0097	5.7	0.0008
Osteopontin*#†	SPP1	6696	Secreted phosphoprotein 1	4.3	0.0097	4.6	0.0007
Ferritin*	FTMT	94033	Ferritin mitochondrial	2.9	0.0151	2.3	0.0026
BCAM†	BCAM	4059	Basal cell adhesion molecule (Lutheran blood group)	2.1	0.0104	2.4	0.0007
PSA-total†	KLK3	354	Kallikrein-related peptidase 3	−2.4	0.0097	−2.3	0.0009
LHCGR†	LHCGR	3973	Luteinising hormone, choriogonadotropin receptor	−1.6	0.0078	−2.0	0.0012
CD40-ligand†	CD40LG	959	CD40 ligand	−1.8	0.0052	−1.6	0.0030
CD30†	TNFRSF8	943	Tumour necrosis factor receptor superfamily, member 8	−1.5	0.0104	−1.7	0.0009
MICB†	MICB	4277	MHC class I polypeptide-related sequence B	−1.5	0.0097	−1.4	0.0019
CA15-3†	MUC1	4852	Mucin 1, cell surface associated	−1.4	0.0104	−1.1	0.0127
Erythropoietin-R†	EPOR	2057	Erythropoietin receptor	−1.4	0.0097	−1.3	0.0052

*Identified by PAM analyses.
†Identified by SAM analyses.
ACLF, acute-on-chronic liver failure; CHB, chronic hepatitis B; MIP-3α, macrophage inflammatory protein 3α; PAM, predictive analyses of microarrays; SAM, significance analyses of microarrays.