Multivariable logistic regression analysis on the influence factors for Helicobacter pylori eradication rate
| Factors | Overall | Male | Female | |||
|---|---|---|---|---|---|---|
| Successful/failed | OR (95% CI) | Successful/failed | OR (95% CI) | Successful/failed | OR (95% CI) | |
| Gender | ||||||
| Female | 17 877/5091 | 1.00 | NA | NA | NA | NA |
| Male | 14 391/6487 | 1.39 (1.32–1.47) | NA | NA | NA | NA |
| Missed doses | ||||||
| No | 30 529/10 479 | 1.00 | 13 530/5855 | 1.00 | 16 999/4624 | 1.00 |
| Yes | 1739/1099 | 1.79 (1.65 to 1.94) | 861/632 | 1.68 (1.50 to 1.87) | 878/467 | 1.94 (1.73 to 2.18) |
| Smoking | ||||||
| No | 27 697/9051 | 1.00 | 9827/3967 | 1.00 | 17 870/5084 | 1.00 |
| Yes | 4568/2526 | 1.28 (1.19 to 1.37) | 4561/2520 | 1.27 (1.18 to 1.35) | 7/6 | 3.32 (1.08 to 10.14) |
| Drinking | ||||||
| No | 26 424/8552 | 1.00 | 8700/3504 | 1.00 | 17 724/5048 | 1.00 |
| Yes | 5841/3025 | 1.16 (1.08 to 1.23) | 5688/2983 | 1.17 (1.10 to 1.25) | 153/42 | 0.90 (0.64 to 1.29) |
| Stomach disease | ||||||
| No | 29 798/10 540 | 1.00 | 13 250/5907 | 1.00 | 16 548/4633 | 1.00 |
| Yes | 2467/1037 | 1.13 (1.05 to 1.22) | 1138/580 | 1.05 (0.95 to 1.17) | 1329/457 | 1.23 (1.10 to 1.38) |
| BMI group* | ||||||
| <25.0 | 21 379/7650 | 1.00 | 9783/4484 | 1.00 | 11 596/3166 | 1.00 |
| 25.0∼ | 10 139/3661 | 1.03 (0.99 to 1.08) | 4472/1950 | 0.96 (0.90 to 1.03) | 5667/1711 | 1.12 (1.05 to 1.20) |
| ≥30.0 | 745/267 | 1.19 (1.03 to 1.37) | 133/53 | 0.88 (0.63 to 1.21) | 612/214 | 1.33 (1.13 to 1.56) |
| Baseline DOB† | ||||||
| Q1 | 8160/2798 | 1.00 | 4428/1832 | 1.00 | 3732/966 | 1.00 |
| Q2 | 8016/2942 | 1.09 (1.03 to 1.16) | 4013/1832 | 1.11 (1.02 to 1.20) | 4003/1110 | 1.07 (0.97 to 1.18) |
| Q3 | 8024/2931 | 1.13 (1.07 to 1.20) | 3420/1627 | 1.16 (1.07 to 1.25) | 4604/1304 | 1.10 (1.00 to 1.21) |
| Q4 | 8068/2889 | 1.19 (1.12 to 1.26) | 2530/1185 | 1.15 (1.05 to 1.26) | 5538/1704 | 1.21 (1.10 to 1.32) |
| Frequency of missed doses‡ | ||||||
| 0 | 30 529/10 479 | 1.00 | 13 530/5855 | 1.00 | 16 999/4624 | 1.00 |
| 1 | 255/106 | 1.19 (0.94 to 1.49) | 118/55 | 1.03 (0.75 to 1.43) | 137/51 | 1.37 (0.99 to 1.90) |
| 2 | 196/87 | 1.32 (1.02 to 1.70) | 74/51 | 1.62 (1.13 to 2.31) | 122/36 | 1.08 (0.74 to 1.57) |
| 3–5 | 241/129 | 1.62 (1.30 to 2.01) | 106/60 | 1.34 (0.97 to 1.84) | 135/69 | 1.91 (1.43 to 2.56) |
| 6–29 | 258/165 | 1.82 (1.49 to 2.22) | 129/76 | 1.32 (0.99 to 1.76) | 129/89 | 2.47 (1.88 to 3.25) |
| Unknown | 789/612 | 2.15 (1.92 to 2.40) | 434/390 | 2.06 (1.79 to 2.37) | 355/222 | 2.29 (1.93 to 2.72) |
| Smoking index§ | ||||||
| 0 | 27 697/9051 | 1.00 | 9827/3967 | 1.00 | 17 870/5084 | 1.00 |
| Q1 | 906/482 | 1.23 (1.08 to 1.38) | 901/481 | 1.22 (1.08 to 1.38) | 5/1 | 0.79 (0.09 to 6.98) |
| Q2+Q3 | 1677/878 | 1.22 (1.11 to 1.34) | 1676/876 | 1.21 (1.10 to 1.33) | 1/2 | 5.78 (0.51 to 64.87) |
| Q4 | 1031/686 | 1.56 (1.40 to 1.74) | 1030/684 | 1.54 (1.37 to 1.72) | 1/2 | 8.26 (0.74 to 92.26) |
| Drinking index¶ | ||||||
| 0 | 26 424/8552 | 1.00 | 8700/3504 | 1.00 | 17 724/5048 | 1.00 |
| Q1 | 1427/690 | 1.11 (1.00 to 1.22) | 1322/664 | 1.14 (1.02 to 1.26) | 105/26 | 0.81 (0.52 to 1.26) |
| Q2+Q3 | 3024/1520 | 1.12 (1.03 to 1.21) | 2981/1505 | 1.13 (1.04 to 1.22) | 43/15 | 1.17 (0.64 to 2.13) |
| Q4 | 1381/813 | 1.29 (1.17 to 1.43) | 1377/812 | 1.30 (1.18 to 1.44) | 4/1 | 0.69 (0.07 to 6.62) |
*Adjusted for sex, age, missed doses, smoking, drinking, history of stomach disease and baseline DOB. Trend test gained Ptrend=0.026 in the whole population, and Ptrend=0.217 and Ptrend<0.001 in men and women, respectively.
†Adjusted for sex, age, missed doses, smoking, drinking, history of stomach disease and BMI. Trend test gained Ptrend<0.001 in the whole population, and Ptrend<0.001 and Ptrend<0.001 in men and women, respectively. Q: quartile, P25=11.20, P50=18.60, P75=29.28.
‡Adjusted for sex, age, smoking, drinking, history of stomach disease, BMI and baseline DOB. Trend test gained Ptrend<0.001 in the whole population, and Ptrend<0.001 and Ptrend<0.001 in men and women, respectively.
§Adjusted for sex, age, missed doses, drinking, history of stomach disease, BMI and baseline DOB. Trend test gained Ptrend<0.001 in the whole population, and Ptrend<0.001 and Ptrend=0.035 in men and women, respectively. Q: quartile, P25=10, P50=20, P75=30.
¶Adjusted for sex, age, missed doses, smoking, history of stomach disease, BMI and baseline DOB. Trend test gained Ptrend<0.001 in the whole population, and Ptrend<0.001 and Ptrend=0.821 in men and women, respectively. Q: quartile, P25=312.0, P50=702.0, P75=1419.6.
BMI, body mass index; DOB, delta over baseline-value.