Pulmonary cytokine concentrations in untreated and microbiota-depleted mice with and without faecal microbiota transplantation during pneumococcal pneumonia
| Untreated | Microbiota depleted | Faeces transplant | |
|---|---|---|---|
| TNF-α | 878.5 (588.5–1185) | 552.9 (476.8–764.2)* | 858.9 (660.4–1564) |
| IL-1 | 122 (61.59–166.8) | 232.5 (143.5–342.1)* | 217 (129–307.1)* |
| IL-6 | 198.9 (95.72–240.2) | 419.4 (279.2–555.6)** | 326.8 (210.8–454.7)* |
| IL-10 | 227.7 (160–300.3) | 123.7 (116.8–128.1)* | 174.4 (153.7–189) |
| CXCL1 | 144.6 (84.43–223.7) | 384.4 (260.3–533.9)*** | 242.9 (185.4–271)* |
Data are expressed as median (IQR) of n=8 mice per group per time point. Measurements are expressed in pg/mL.
*p<0.05 for Untreated versus Microbiota depleted or for Untreated versus Faeces transplant mice (Mann–Whitney U test).
**p<0.01 for Untreated versus Microbiota depleted or for Untreated versus Faeces transplant mice (Mann–Whitney U test).
***p<0.001 for Untreated versus Microbiota depleted or for Untreated versus Faeces transplant mice (Mann–Whitney U test).
CXCL1, (C-X-C motif) ligand 1; IL, interleukin; TNF-α, a tumour necrosis factor-α.