Variable | Corticosteroid requirement | Hospitalisation for acute severe colitis | Colectomy | |||
---|---|---|---|---|---|---|
Univariate analysis† | Multivariate analysis† | Univariate analysis† | Multivariate analysis† | Univariate analysis† | Multivariate analysis† | |
Age‡ | 0.96 (0.8–1.1), p=0.59 | 1.16 (0.9–1.5), p=0.29 | 1.37 (0.9–2.0), p=0.11 | |||
Sex§ | 0.70 (0.4–1.2), p=0.20 | 1.05 (0.4–2.6), p=0.91 | 2.52 (0.7–8.7), p=0.14 | |||
Disease duration¶ | 0.90 (0.8–1.0), p=0.05* | 0.91 (0.8–1.1), p=0.36 | 0.92 (0.7–1.2), p=0.47 | 1.06 (0.8–1.4), p=0.65 | ||
Disease extent** | 0.94 (0.5–1.8), p=0.86 | 2.62 (1.0–6.7), p=0.04* | 3.21 (1.1–8.6), p=0.02* | 3.67 (1.1–12.1), p=0.03* | 4.06 (1.3–16.2), p=0.02* | |
Maintenance therapy†† | ||||||
5ASA | 0.93 (0.4, 2.3), p=0.01†† | 0.72 (0.3–1.9), p=0.57†† | 0.78 (0.2–3.9), p=0.03†† | 0.46 (0.1–2.5), p=0.66†† | ||
Other | 2.08 (0.9–5.0) | 0.98 (0.4–2.7) | 1.70 (0.4–7.7) | 0.69 (0.1–3.6) | ||
Histological remission | 0.35 (0.2–0.6), p<0.001* | 0.42 (0.2–0.9), p=0.02* | 0.22 (0.1–0.7), p=0.007* | 0.21 (0.1–0.7), p=0.02* | 0.32 (0.1–1.2), p=0.10 | 0.36 (0.1–1.8), p=0.22 |
Endoscopic remission | 0.47 (0.3–0.8), p=0.005* | 0.86 (0.5–1.7), p=0.65 | 0.48 (0.2–1.2), p=0.12 | 0.83 (0.3–2.4), p=0.74 | 0.50 (0.2–1.6), p=0.25 | 0.71 (0.2–3.0), p=0.64 |
Endoscopic and histological remission‡‡ | 0.36 (0.8–0.6), p<0.001 | 0.38 (0.2–0.9), p=0.02* | 0.27 (0.1–0.8), p=0.02* | 0.24 (0.1–0.9), p=0.04* | 0.41 (0.1–1.5), p=0.19 | 0.46 (0.1–2.8), p=0.39 |
†Cox regression univariate and multivariate analyses presented. Data presented: HR (CI), p value. p Value of ≤0.05 considered significant and marked by*.
‡HR given per 10-year increase in age.
§HR for male gender with female gender as comparator.
¶HR given per 5-year increase in disease duration.
**Extensive versus non-extensive disease.
††Compared with no therapy as comparator group, overall p value for difference between maintenance groups provided.
‡‡Combined endoscopic and histological remission analysed in a separate multivariate model.
5ASA, 5-aminosalicylic acid.