Univariable analysis and best fitting multiple logistic regression model for factors associated with high grade dysplasia (HGD) or cancer in sessile serrated adenomas/polyps ≥20mm
| Univariable analysis | Best fitting multiple logistic regression model | ||||
|---|---|---|---|---|---|
| No HGD or cancer | HGD or cancer | p Value | Adjusted OR (95% CI) | p Value | |
| Age, years (median, IQR) | 64.0 (49–79) | 67.0 (45–89) | 0.046 | 2.0 (1.13 to 3.56) | 0.017 |
| Sex (n, %) | |||||
| Male | 79 (41.1%) | 8 (53.3%) | 0.36 | ||
| Female | 113 (58.9%) | 7 (46.7%) | |||
| ASA grade (n, %)* | |||||
| ASA 1 or 2 | 175 (91.6%) | 12 (80.0%) | 0.15 | ||
| ASA 3+ | 16 (8.4%) | 3 (20.0%) | |||
| Previous attempt at EMR (n, %) | |||||
| No | 175 (91.1%) | 14 (93.3%) | |||
| Yes | 17 (8.9%) | 1 (6.7%) | 0.77 | ||
| Size, mm (median, IQR)† | 25 (10–40) | 30 (15–45) | 0.011 | ||
| Lesion size (n, %)* | |||||
| 20 mm | 68 (35.6%) | 0 (0.0%) | 0.035 | ||
| 21–30 mm | 73 (38.2%) | 8 (53.3%) | |||
| 31–40 mm | 33 (17.3%) | 4 (26.7%) | |||
| >40 mm | 17 (8.9%) | 3 (20.0%) | |||
| Location group (n, %) | |||||
| Distal colon | 20 (10.4%) | 1 (6.7%) | 0.72 | ||
| Proximal colon (splenic flexure and proximal) | 172 (89.6%) | 14 (93.3%) | |||
| Paris classification (n, %) | |||||
| 0-IIa | 147 (76.6%) | 5 (33.3%) | 0.009 | ||
| 0-Is | 16 (8.3%) | 5 (33.3%) | |||
| 0-IIa+Is | 12 (6.3%) | 4 (26.7%) | |||
| 0-IIb | 13 (6.8%) | 0 (0.0%) | |||
| Other | 4 (2.0%) | 1 (6.7%) | |||
| Paris classification† (n, %) | <0.001 | ||||
| No 0-Is component | 164 (85.4%) | 6 (40.0%) | <0.001 | 1 | |
| Any 0-Is component | 28 (14.6%) | 9 (60.0%) | 10.2 (3.18 to 32.4) | ||
| Highest Kudo classification† (n, %)* | |||||
| Kudo I and II | 117 (62.9%) | 3 (20.0%) | 0.001 | ||
| Kudo III, IV, V | 69 (37.1%) | 12 (80.0%) | |||
Adjusted OR 2.0 (1.13 to 3.56)**=per decade.
Bold indicates p values <0.005.
*Data missing ASA n=1, Size n=1, Kudo n=6.
†Included in multivariable analysis.
ASA, American Society of Anaesthesiologists; EMR, endoscopic mucosal resection.