Cox regression analysis of baseline factors associated with mortality in the training cohort
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Gender* | 0.687 (0.302 to 1.564) | 0.371 | ||
| Age, years | 0.989 (0.956 to 1.024) | 0.540 | ||
| Aetiology | 1.587 (0.845 to 2.980) | 0.151 | ||
| Treatment (yes/no)† | 0.919 (0.844 to 1.000) | 0.051 | 0.460 (0. 0.213 to 0.997) | 0.049 |
| Edmondson–Steiner grading | 1.443 (1.571 to 2.398) | 0.036 | 1.438 (0.882 to 2.345) | 0.145 |
| Macrovascular invasion | 4.818 (2.140 to 10.846) | <0.0001 | 3.885 (1.491 to 10.123) | 0.005 |
| Tumour volume at baseline | 1.003 (0.518 to 1.944) | 0.993 | ||
| Platelets (×103/mm3) | 0.586 (0.271 to 1.268) | 0.586 | ||
| Albumin (g/dL) | 0.492 (0.253 to 0.882) | 0.017 | 0.403 (0.211 to 0.769) | 0.006 |
| Creatinine (mg/dL) | 1.111 (0.515 to 2.397) | 0.788 | ||
| Bilirubin (mg/dL) | 1.069 (0.964 to 1.185) | 0.207 | ||
| AFP (ng/mL) | 1.153 (0.776 to 1.712) | 0.481 | ||
| Five-gene risk signature | 1.548 (1.296 to 1.849) | <0.0001 | 3.987 (1.941 to 8.193) | <0.0001 |
*Male gender used as reference.
†No treatment used as reference.
AFP, α-fetoprotein.