Interaction of CTRC variants with (A) p.N34S SPINK1 and (B) p.L26V CTSB mutations
| CTRC/p.N34S SPINK1 positive (%) | CTRC/p.N34S SPINK1 negative (%) | |
| (A) | ||
| TCP (n=480) | 15/148 (10.1) | 41/332 (12.3) |
| ICP (n=87) | 5/31 (16.1) | 7/56 (12.5) |
| Total (n=567) | 20/179 (11.2) | 48/388 (12.4) |
| CTRC/p.L26V CTSB positive (%) | CTRC/p.L26V CTSB negative (%) | |
| (B) | ||
| TCP (n=433) | 26/255 (10.2) | 25/178 (14.0) |
| ICP (n=83) | 7/42 (16.7) | 4/41 (9.8) |
| Total (n=516) | 33/297 (11.1) | 29/219 (13.2) |
(A) TCP: OR 0.79, 95% CI 0.40 to 1.54, p=0.46; ICP: OR 1.35, 95% CI 0.33 to 5.39, p=0.88; Total CP: OR 0.88, 95% CI 0.49 to 1.59, p=0.66.
(B) TCP: OR 0.69, 95% CI 0.37 to 1.30, p=0.22; ICP: OR 1.85, 95% CI 0.43 to 1.86, p=0.35; Total CP: OR 0.82, 95% CI 0.47 to 1.44, p=0.46.
CP, chronic pancreatitis; ICP, idiopathic chronic pancreatitis; n, number of individuals; TCP, tropical calcific pancreatitis.