Reclassification table for HLA-only versus combined HLA and GRS_26 in the test set of 985 individuals
| HLA only | HLA and GRS_26 | |||
|---|---|---|---|---|
| <25% | 25–75% | >75% | Reclassified% | |
| <25% | ||||
| Total | 243 | 0 | 0 | 0 |
| Cases | 17 | 0 | 0 | 0 |
| Controls | 226 | 0 | 0 | 0 |
| 25–75% | ||||
| Total | 9 | 477 | 78 | 0.15 |
| Cases | 0 | 102 | 48 | 0.32 |
| Controls | 9 | 375 | 30 | 0.09 |
| >75% | ||||
| Total | 0 | 5 | 173 | 0.03 |
| Cases | 0 | 1 | 109 | 0.01 |
| Controls | 0 | 4 | 64 | 0.06 |
| NRI (95% CI) | 0.146 (0.093 to 0.199); p=0.0001 | |||
| IDI (95% CI) | 0.025 (0.014 to 0.037); p=0.0001 | |||
GRS, genetic risk score; IDI, integrated discrimination improvement; NRI, net reclassification index.