HLA only | HLA and GRS_10 | HLA and GRS_26 | HLA and GRS_57 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
<25% | 25–75% | >75% | Reclassified% | <25% | 25–75% | >75% | Reclassified% | <25% | 25–75% | >75% | Reclassified% | |
<25% | ||||||||||||
Total | 1419 | 0 | 0 | 0 | 1419 | 0 | 0 | 0 | 1419 | 0 | 0 | 0 |
Cases | 114 | 0 | 0 | 0 | 114 | 0 | 0 | 0 | 114 | 0 | 0 | 0 |
Controls | 1305 | 0 | 0 | 0 | 1305 | 0 | 0 | 0 | 1305 | 0 | 0 | 0 |
25–75% | ||||||||||||
Total | 64 | 2710 | 189 | 0.09 | 104 | 2562 | 297 | 0.14 | 261 | 2389 | 313 | 0.19 |
Cases | 12 | 1444 | 134 | 0.09 | 16 | 1354 | 220 | 0.15 | 49 | 1300 | 241 | 0.18 |
Controls | 52 | 1266 | 55 | 0.08 | 88 | 1208 | 77 | 0.12 | 212 | 1089 | 72 | 0.21 |
>75% | ||||||||||||
Total | 0 | 39 | 1069 | 0.04 | 0 | 81 | 1027 | 0.07 | 0 | 77 | 1031 | 0.07 |
Cases | 0 | 24 | 947 | 0.02 | 0 | 52 | 919 | 0.05 | 0 | 52 | 919 | 0.05 |
Controls | 0 | 15 | 122 | 0.11 | 0 | 29 | 108 | 0.21 | 0 | 25 | 112 | 0.18 |
NRI (95% CI) | 0.041 (0.029 to 0.053); p=0.0001 | 0.071 (0.055 to 0.087); p=0.0001 | 0.111 (0.093–0.129); p=0.0001 | |||||||||
IDI (95% CI) | 0.021 (0.018 to 0.025); p=0.0001 | 0.031 (0.027 to 0.036); p=0.0001 | 0.054 (0.048–0.060); p=0.0001 |
GRS, genetic risk score; IDI, integrated discrimination improvement; NRI, net reclassification index.