Table 2

Reclassification table of individuals of predicted risk using HLA-only versus combined HLA and GRS_10, GRS_26 and GRS_57 (low risk <25%, intermediate risk 25–75%, high risk >75%)

HLA only	HLA and GRS_10				HLA and GRS_26				HLA and GRS_57
HLA only	<25%	25–75%	>75%	Reclassified%	<25%	25–75%	>75%	Reclassified%	<25%	25–75%	>75%	Reclassified%
<25%
Total	1419	0	0	0	1419	0	0	0	1419	0	0	0
Cases	114	0	0	0	114	0	0	0	114	0	0	0
Controls	1305	0	0	0	1305	0	0	0	1305	0	0	0
25–75%
Total	64	2710	189	0.09	104	2562	297	0.14	261	2389	313	0.19
Cases	12	1444	134	0.09	16	1354	220	0.15	49	1300	241	0.18
Controls	52	1266	55	0.08	88	1208	77	0.12	212	1089	72	0.21
>75%
Total	0	39	1069	0.04	0	81	1027	0.07	0	77	1031	0.07
Cases	0	24	947	0.02	0	52	919	0.05	0	52	919	0.05
Controls	0	15	122	0.11	0	29	108	0.21	0	25	112	0.18
NRI (95% CI)	0.041 (0.029 to 0.053); p=0.0001				0.071 (0.055 to 0.087); p=0.0001				0.111 (0.093–0.129); p=0.0001
IDI (95% CI)	0.021 (0.018 to 0.025); p=0.0001				0.031 (0.027 to 0.036); p=0.0001				0.054 (0.048–0.060); p=0.0001

GRS, genetic risk score; IDI, integrated discrimination improvement; NRI, net reclassification index.